基因總覽
ZFP36 zinc finger CCCH-type 是由 ZFP36 編碼的蛋白質，屬於 CCCH-type 鋅指 RNA 結合蛋白。其蛋白質由 326 個胺基酸組成，帶有兩個 C3H1-type zinc finger domains，並含有數段 P-P-P-P-G 重複序列。這些結構特徵與其辨識 RNA 及連結 mRNA 調控途徑的能力相關。ZFP36 可在細胞核與細胞質之間移動，參與細胞質 RNA 調控，也具有核內前體 mRNA 處理相關作用；其主要角色是調節多種 mRNA 的穩定性與表現。
基因異名與舊稱
異名取自 HGNC，可能包含歷史名稱；蛋白質名稱以 UniProt 註解為準。
染色體位置與基因結構
查看實際轉錄本與 exon 註解
| Transcript | Genomic coordinates | Exons |
|---|---|---|
| ENST00000597629 ★ | 39,406,847–39,409,407 | 2 |
| ENST00000918416 | 39,406,412–39,409,407 | 2 |
| ENST00001102433 | 39,406,412–39,409,407 | 2 |
| ENST00001122778 | 39,406,412–39,409,413 | 2 |
| ENST00001122779 | 39,406,412–39,409,407 | 2 |
| ENST00001130473 | 39,406,412–39,411,635 | 2 |
| ENST00000594045 | 39,406,857–39,408,179 | 2 |
顯示 7/7 個蛋白質編碼轉錄本；canonical 優先。
帶型與著絲點依 Ensembl 座標繪製；核染色體長度以 GRCh38 第 1 號染色體為共同尺度。黃色標記表示本基因位置，細小區間加粗以利辨識；實際基因長度與 exon 見下方資料。
分子功能與生物學過程
ZFP36 主要辨識多種 mRNA 3′ 非翻譯區中的 AU-rich element（ARE），並充當 RNA 結合接頭，將相關訊號連結至 mRNA 降解機制。它促進 ARE-mRNA 的 poly(A) 尾移除（去腺苷化），使轉錄本較不穩定，進而降低其支持蛋白質合成的能力。ZFP36 也會招募細胞質 RNA 降解因子；它與 CNOT1 的結合可招募去腺苷化酶 CNOT7，並可能連結 CCR4-NOT complex。ZFP36 還能促進目標 RNA 去帽，並將 ARE-mRNA 導向 processing bodies。它也與 argonaute RISC 催化成分合作，協助 microRNA 對含 ARE 的 mRNA 進行調控。其自身 mRNA 含有可被辨識的 ARE，因此 ZFP36 也能藉由促進自身轉錄本降解形成自我調節。除了 ARE 轉錄本，來源亦指出它可在轉錄後層級調控非 ARE 目標，例如 MHC class I mRNA；在細胞核中，它會影響前體 mRNA 處理，並在 LPS 刺激的巨噬細胞中抑制 PABPN1 刺激的核內 polyadenylation 活性。它也參與 stress granule 與 P-body 的形成和融合調節。
這些作用涉及多種細胞情境。於 IFN 和／或 LPS 誘導的巨噬細胞中，ZFP36 促進 TNF 及其他發炎相關 ARE-mRNA 降解，與限制發炎反應有關；它也參與樹突細胞成熟的轉錄後調控，形成限制發炎反應的負回饋。內皮細胞缺氧反應中，ZFP36 促進 HIF1A mRNA 降解。來源亦指出，它可促進前脂肪細胞早期脂肪生成，並透過促進 STAT5B mRNA 降解而負向調節造血／紅系細胞分化；在骨骼肌衛星細胞中，促進 MYOD1 mRNA 降解與維持細胞靜止狀態有關。此外，ZFP36 參與角質形成細胞增殖、分化與凋亡的調節，並在乳癌細胞中藉由抑制細胞增殖發揮腫瘤抑制作用。微生物感染相關資料則指出，ZFP36 負向調節 HTLV-1 TAX 依賴的病毒長末端重複序列啟動子轉錄活化。
Promoter 與基因調控
>ZFP36 ENST00000597629 GRCh38 chr19:39405847-39406947 strand=1 5′→3′ 相對 TSS：-1000 到 +100 bp；1101 bp 依轉錄本 TSS 擷取的基因組序列；TSS = 0，兩端包含，未驗證為 promoter CCTCCAAGGCCTGCTGGCTCTTTCTTGGCACTTTGCTCTGCAGATTTCTTTCCGTAAGTGCTTATTTCTC ACAGTCTTTCTCCTTTTTGTCCAGTTTCTTTTTCTTTTTAATTTTTTTAAATAGTATTTTTTGTAGACAT GGGATCTCACTGTTGCCCAGGCTGATCTTGAACTCCTGATCTCAGGTAATCCACCTGCCTCATCCTCTGA AAGTACTGGGATTGGCCGGGCTTGGTGGCTCACACCTGTAATTCCAGCTCTTTGGGAGGCGGAGGTGGGA GGATCGCTTGAGCCCCGGAGCTGGAGATTAGCCTGGGCAACATAGGGAAACCCCGTCTTTCAAAAAAAAA AAAAAAGAAGAAGAAAAAGGAAAGAAAAACACAAAAAGTGCTGGGATCACAGGTGTGAGCCACTGCGCTC AGCCCCTTTCTGTTTCTTTTTGTGATCCTCCCAACCCTCTTCTCCCTCTGAATCTGTCTCTGGGACTGTC TCTGTCTCCCCGTCTTCCCTCCCTTCCTCACCCTGTCTATCTCTCTCTGTATGTCTCTTGGTGTGTGTGT CTCTCTCGATGTTTTTCTCTCTGCCTGTCTGCCTGTCTGTACCCCTCTGCGTCTCTCCCCGCCCCCATCC GTCTGTGTCGCACGCGCACCCCCATCGGGCTTCTGCTCTTGTCAATTGCCCCTGGGGCCCTGCCCCCACC TCCGCCCCAGTTTCCTTCTACAAGCCTCAGTCTCCAGCTTTGAAAACTGGGCAGGCGTCCCCCCATCCGC ACCCCCACCCCTTCCCCACGCATTCCCCGCTCGGTCACGGCTGTCCACCGGCCAAGCTCAGGCGCGTCCT GGCCCAGGGCCGGGCGGAAGGGAACCAGTCCAGGGCCAGCCAGGCTGCGCCGGGGGCGCGCGTCCGGGAA GCGCCCCTCCTGCCCCGCCCCCGGCCCCGGCCCCGGCCCCGCCCCGTGCTTGCAGTTTCCTATAAGTAGC CGGCTCTCGGTGCCAGCCTCAGCCTGACTTCAGCGCTCCCACTCTCGGCCGACACCCCTCATGGCCAACC GTTACACCATGGATCTGACTGCCATCTACGAGGTGAGTCCCCGCCGCACGG
EPDnew 實驗支持 promoter／TSS · 1 筆
| EPDnew ID | TSS（1-based） | 股向 | 來源顯示區間 |
|---|---|---|---|
| ZFP36_1 ↗ | 19:39,406,847 | 正股 | 39,406,798–39,406,857 |
EPDnew human v006 · UCSC hg38，GRCh38/hg38，透過 UCSC 取得。TSS 具有 CAGE／RAMPAGE 等實驗資料支持；任意擷取的上下游區間仍需另行判讀調控功能，不能視為整段皆經功能驗證。
EPD 封存狀態 ↗ · UCSC 資料說明 ↗ · EPD team, SIB Swiss Institute of Bioinformatics; UCSC Genome Browser · CC BY 4.0
ZFP36 表現會隨細胞刺激而上升：T 細胞活化可使其上調；角質形成細胞受傷後，在表皮修復期間表現顯著增加，也可受 EGF、TNF、GM-CSF、FGF1 及 dexamethasone 誘導。LPS 可在 p38 MAPK 依賴的條件下提高其表現；蛋白質層級的上調則與 p38 MAPK 和 ERK 有關。
蛋白質結構域與序列
參考蛋白質長度：326 aa
ZFP36 長 326 個胺基酸，具有兩個 C3H1-type zinc finger domains，並含有三段 P-P-P-P-G 重複序列。RNA 結合所需區域位於胺基酸 97–173；胺基酸 1–100 與 174–326 區段分別具有 mRNA 降解活化相關功能。N 端 1–15 個胺基酸對核輸出必要，95–168 區段對核定位必要。胺基酸 312–326 區域參與與 CNOT1 的交互作用；多個區段亦與 ARE-mRNA 導向 P-body 有關。
蛋白質三維結構
細胞內定位
ZFP36 可在細胞核與細胞質間穿梭，且此移動依賴 CRM1。 其細胞質分布可受 p38 MAPK 與 YWHAB 影響；能進出 P-body 與 stress granule，能量缺乏時會定位至 stress granule。 經 MAPKAPK2 依賴的磷酸化後，ZFP36 可被排除於 stress granule。 HTLV-1 感染相關資料則指出，ZFP36 與 TAX 在細胞核及細胞質中共定位。
深綠色圓點：來源記載的蛋白質定位；數量不表示含量。
未繪示構造：Cytoplasmic granule。這些構造未在通用細胞圖中標點，仍保留來源定位名稱。
動物細胞結構示意；器官大小與數量不按比例。點選細胞構造可查看定位註解。
交互作用與訊號網絡
拖曳節點後放開可帶動位置變化；點選夥伴查看證據。位置與連線長度不代表結合強度，圖中未推定夥伴彼此之間的關係。
更多交互作用夥伴 · 已取得 8 個夥伴
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- FHL3Q13643 · UniProt INTERACTION · 4 experiments
- JPH3Q8WXH2 · UniProt INTERACTION · 3 experiments
- PECAM1P16284 · UniProt INTERACTION · 3 experiments
- RUNX1T1Q06455-2 · UniProt INTERACTION · 3 experiments
- VIMP08670 · UniProt INTERACTION · 3 experiments
ZFP36 與 CCR4-NOT、PAN2-PAN3 去腺苷化複合體及 RNA exosome 有關聯，並可與 CNOT1、CNOT7、DCP1A、DCP2、EXOSC2、XRN1 等 mRNA 降解因子實際交互作用。其與 CNOT1、CNOT7 的結合可促進 mRNA 去腺苷化；此外也能與 AGO2、AGO4 及多種 14-3-3 蛋白交互作用。磷酸化狀態會影響部分結合與定位，但來源指出，與 14-3-3 的特定交互作用不會阻止 CCR4-NOT 招募或 ARE-mRNA 降解。感染情境下，ZFP36 C 端與 HTLV-1 TAX C 端交互作用，並抑制 TAX 活化病毒 LTR 啟動子。
疾病與遺傳關聯
Contextual Functional Evidence Matrix
矩陣以「功能主張」為列，以細胞情境、干預條件、量測結果與證據來源為欄，方便比較同一功能在不同條件下的支持情形。只有含情境與實驗資訊的紀錄會列入矩陣；一般功能註解另列於下方。
功能註解總覽 · 7 筆
| 功能面向 | 功能敘述 | 證據類型 | 可查核來源 |
|---|---|---|---|
| 功能 | ZFP36 是鋅指 RNA 結合蛋白，可辨識多種 mRNA 3′ 非翻譯區中的 ARE，並促進其去腺苷化及降解，以調節蛋白質合成。它可招募 mRNA 降解因子，經 CNOT1 連結 CNOT7（可能也包括 CCR4-NOT），並參與自我 mRNA 降解、去帽、P-body 導引及 miRNA 協同調控。其作用涉及發炎、缺氧、脂肪生成、血球分化、肌肉衛星細胞靜止、角質形成細胞調節與乳癌細胞增殖；部分敘述標示為相似性推論。 | 含實驗來源 | 證據與來源Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs. May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro. Involved in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells PMID 10330172 ↗ · PMID 10751406 ↗ · PMID 11279239 ↗ · PMID 11719186 ↗ · PMID 12115244 ↗ · PMID 12748283 ↗ · PMID 15187101 ↗ · PMID 15634918 ↗ · PMID 15687258 ↗ · PMID 15766526 ↗ · PMID 16364915 ↗ · PMID 16702957 ↗ · PMID 17030620 ↗ · PMID 17369404 ↗ · PMID 18367721 ↗ · PMID 19188452 ↗ · PMID 20221403 ↗ · PMID 20702587 ↗ · PMID 21775632 ↗ · PMID 23644599 ↗ · PMID 25815583 ↗ · PMID 26926077 ↗ · PMID 27182009 ↗ · PMID 27193233 ↗ · PMID 31439631 ↗ · PMID 9703499 ↗ |
| 功能 | 在微生物感染情境中，ZFP36 負向調節 HTLV-1 TAX 依賴的病毒長末端重複序列（LTR）啟動子轉錄活化。 | 含實驗來源 | 證據與來源(Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter PMID 14679154 ↗ |
| 交互作用 | ZFP36 與 CCR4-NOT、PAN2-PAN3 去腺苷化複合體及 RNA exosome 等 RNA 降解因子關聯，並可結合 CNOT1、CNOT7、去帽酶及核酸外切酶。它也與 AGO、14-3-3、PABPN1 等多種蛋白交互作用；其中部分結合受 RNA、磷酸化或刺激條件影響。14-3-3 相關定位調節不必然阻止 CCR4-NOT 招募或 ARE-mRNA 降解；若干敘述依相似性推論。 | 含實驗來源 | 證據與來源Associates with cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to trigger ARE-containing mRNA deadenylation and decay processes (By similarity). Part of a mRNA decay activation complex at least composed of poly(A)-specific exoribonucleases CNOT6, EXOSC2 and XRN1 and mRNA-decapping enzymes DCP1A and DCP2. Associates with the RNA exosome complex. Interacts (via phosphorylated form) with 14-3-3 proteins; these interactions promote exclusion of ZFP36 from cytoplasmic stress granules in response to arsenite treatment in a MAPKAPK2-dependent manner and does not prevent CCR4-NOT deadenylase complex recruitment or ZFP36-induced ARE-containing mRNA deadenylation and decay processes (By similarity). Interacts with 14-3-3 proteins; these interactions occur in response to rapamycin in an Akt-dependent manner. Interacts with AGO2 and AGO4. Interacts (via C-terminus) with CNOT1; this interaction occurs in a RNA-independent manner and induces mRNA deadenylation. Interacts (via N-terminus) with CNOT6. Interacts with CNOT6L (By similarity). Interacts (via C-terminus) with CNOT7; this interaction occurs in a RNA-independent manner, induces mRNA deadenylation and is inhibited in a phosphorylation MAPKAPK2-dependent manner. Interacts (via unphosphorylated form) with CNOT8; this interaction occurs in a RNA-independent manner and is inhibited in a phosphorylation MAPKAPK2-dependent manner (By similarity). Interacts with DCP1A. Interacts (via N-terminus) with DCP2. Interacts with EDC3. Interacts (via N-terminus) with EXOSC2. Interacts with heat shock 70 kDa proteins. Interacts with KHSRP; this interaction increases upon cytokine-induced treatment. Interacts with MAP3K4; this interaction enhances the association with SH3KBP1/CIN85. Interacts with MAPKAPK2; this interaction occurs upon skeletal muscle satellite cell activation (By similarity). Interacts with NCL. Interacts with NUP214; this interaction increases upon lipopolysaccharide (LPS) stimulation. Interacts with PABPC1; this interaction occurs in a RNA-dependent manner. Interacts (via hypophosphorylated form) with PABPN1 (via RRM domain and C-terminal arginine-rich region); this interaction occurs in the nucleus in a RNA-independent manner, decreases in presence of single-stranded poly(A) RNA-oligomer and in a p38 MAPK-dependent-manner and inhibits nuclear poly(A) tail synthesis (By similarity). Interacts with PAN2 (By similarity). Interacts (via C3H1-type zinc finger domains) with PKM. Interacts (via C3H1-type zinc finger domains) with nuclear RNA poly(A) polymerase (By similarity). Interacts with PPP2CA; this interaction occurs in LPS-stimulated cells and induces ZFP36 dephosphorylation, and hence may promote ARE-containing mRNAs decay (By similarity). Interacts (via C-terminus) with PRR5L (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress. Interacts (via C-terminus) with SFN; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts (via extreme C-terminal region) with SH3KBP1/CIN85 (via SH3 domains); this interaction enhances MAP3K4-induced phosphorylation of ZFP36 at Ser-66 and Ser-93 and does not alter neither ZFP36 binding to ARE-containing transcripts nor TNF mRNA decay. Interacts with XRN1. Interacts (via C-terminus and Ser-186 phosphorylated form) with YWHAB; this interaction occurs in a p38/MAPKAPK2-dependent manner, increases cytoplasmic localization of ZFP36 and protects ZFP36 from Ser-186 dephosphorylation by serine/threonine phosphatase 2A, and hence may be crucial for stabilizing ARE-containing mRNAs (By similarity). Interacts (via phosphorylated form) with YWHAE (By similarity). Interacts (via C-terminus) with YWHAG; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts with YWHAH; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts with YWHAQ; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts with (via C-terminus) YWHAZ; this interaction occurs in a phosphorylation-dependent manner (By similarity). Interacts (via P-P-P-P-G repeats) with GIGYF2; the interaction is direct (By similarity) PMID 11719186 ↗ · PMID 14766228 ↗ · PMID 15687258 ↗ · PMID 15766526 ↗ · PMID 16126846 ↗ · PMID 16364915 ↗ · PMID 16702957 ↗ · PMID 20221403 ↗ · PMID 21964062 ↗ · PMID 23644599 ↗ · PMID 25106868 ↗ · PMID 26926077 ↗ |
| 交互作用 | 微生物感染情境中，ZFP36 透過 C 端與 HTLV-1 TAX 的 C 端交互作用；此結合會抑制 HTLV-1 TAX 對病毒長末端重複序列（LTR）啟動子的轉錄活化。 | 含實驗來源 | 證據與來源(Microbial infection) Interacts (via C-terminus) with HTLV-1 TAX (via C-terminus); this interaction inhibits HTLV-1 TAX to transactivate viral long terminal repeat (LTR) promoter PMID 14679154 ↗ |
| 細胞定位 | ZFP36 在細胞核與細胞質間依賴 CRM1 穿梭，並可進出 P-body 與 stress granule。它在 p38 MAPK 和 YWHAB 依賴條件下主要位於細胞質；能量缺乏時可進入 stress granule，而 MAPKAPK2 依賴的磷酸化會使其排除於該顆粒。它也可定位於 processing body，並與 SH3KBP1、MAP3K4 在細胞質共定位。 | 含實驗來源 | 證據與來源Nucleus; Cytoplasm; Cytoplasmic granule; Cytoplasm, P-body; Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (By similarity). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (By similarity). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm. Component of cytoplasmic stress granules (SGs) (By similarity). Localizes to cytoplasmic stress granules upon energy starvation. Localizes in processing bodies (PBs). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (By similarity). Shuttles in and out of both cytoplasmic P-body and SGs (By similarity) PMID 15014438 ↗ · PMID 27182009 ↗ · PMID 10330172 ↗ · PMID 12115244 ↗ · PMID 14766228 ↗ · PMID 20221403 ↗ · PMID 17369404 ↗ |
| 細胞定位 | 在微生物感染情境中，ZFP36 位於細胞核與細胞質，並與 HTLV-1 TAX 在兩處共定位；細胞質中的共定位區域位於細胞核周圍。 | 含實驗來源 | 證據與來源Nucleus; Cytoplasm; (Microbial infection) Colocalizes with HTLV-1 TAX in the nucleus and the cytoplasm in a region surrounding the nucleus PMID 14679154 ↗ |
| 調控 | ZFP36 可因 T 細胞活化而上調，也會在角質形成細胞受傷及表皮修復期間增加。角質形成細胞中的強烈誘導因子包括 EGF 與 TNF，GM-CSF 和 FGF1 則造成中度上調，dexamethasone 也可誘導其表現。LPS 可透過 p38 MAPK 依賴途徑上調 ZFP36；蛋白質層級的上調另涉及 ERK。 | 含實驗來源 | 證據與來源Up-regulated by T cell activation. Up-regulated in keratinocytes in response to wounding. Up-regulated by lipopolysaccharide (LPS) in a p38 MAPK- and ERK-dependent manner (at protein level). Up-regulated strongly during epidermal repair after wounding in keratinocytes. Up-regulated strongly by epidermal growth factor (EGF) and tumor necrosis factor (TNF) in keratinocytes. Up-regulated moderately by granulocyte macrophage colony-stimulating factor (GM-CSF) and fibroblast growth factor (FGF1) in keratinocytes. Up-regulated also by glucocorticoid dexamethasone in keratinocytes. Up-regulated by LPS in a p38 MAPK-dependent manner PMID 14766228 ↗ · PMID 15187101 ↗ · PMID 15634918 ↗ · PMID 16508015 ↗ · PMID 20166898 ↗ · PMID 27182009 ↗ |
核酸與蛋白質序列
AGCCTGACTTCAGCGCTCCCACTCTCGGCCGACACCCCTC40ATGGCCAACCGTTACACCATGGATCTGACTGCCATCTACG80AGAGCCTCCTGTCGCTGAGCCCTGACGTGCCCGTGCCATC120CGACCATGGAGGGACTGAGTCCAGCCCAGGCTGGGGCTCC160TCGGGACCCTGGAGCCTGAGCCCCTCCGACTCCAGCCCGT200CTGGGGTCACCTCCCGCCTGCCTGGCCGCTCCACCAGCCT240AGTGGAGGGCCGCAGCTGTGGCTGGGTGCCCCCACCCCCT280GGCTTCGCACCGCTGGCTCCCCGCCTGGGCCCTGAGCTGT320CACCCTCACCCACTTCGCCCACTGCAACCTCCACCACCCC360CTCGCGCTACAAGACTGAGCTATGTCGGACCTTCTCAGAG400AGTGGGCGCTGCCGCTACGGGGCCAAGTGCCAGTTTGCCC440ATGGCCTGGGCGAGCTGCGCCAGGCCAATCGCCACCCCAA480ATACAAGACGGAACTCTGTCACAAGTTCTACCTCCAGGGC520CGCTGCCCCTACGGCTCTCGCTGCCACTTCATCCACAACC560CTAGCGAAGACCTGGCGGCCCCGGGCCACCCTCCTGTGCT600TCGCCAGAGCATCAGCTTCTCCGGCCTGCCCTCTGGCCGC640CGGACCTCACCACCACCACCAGGCCTGGCCGGCCCTTCCC680TGTCCTCCAGCTCCTTCTCGCCCTCCAGCTCCCCACCACC720ACCTGGGGACCTTCCACTGTCACCCTCTGCCTTCTCTGCT760GCCCCTGGCACCCCCCTGGCTCGAAGAGACCCCACCCCAG800TCTGTTGCCCCTCCTGCCGAAGGGCCACTCCTATCAGCGT840CTGGGGGCCCTTGGGTGGCCTGGTTCGGACCCCCTCTGTA880CAGTCCCTGGGATCCGACCCTGATGAATATGCCAGCAGCG920GCAGCAGCCTGGGGGGCTCTGACTCTCCCGTCTTCGAGGC960cDNA 使用 DNA 字母 T；mRNA 模式改以 U 顯示。轉錄本保留已註解的非編碼區，未另外加入 poly(A) 尾；非編碼 RNA 的參考轉錄本也可能仍需後續加工。數字為所選序列的 1-based 位置。長序列以黃色捲軸瀏覽，可複製或下載完整轉錄本與蛋白質；基因組 DNA 隨捲動取得所需範圍。