基因總覽
UGT2B7 是一個蛋白質編碼基因，其產物正式名稱為 UDP glucuronosyltransferase family 2 member B7，也稱 UDP-glucuronosyltransferase 2B7。此蛋白屬於 UDP-glycosyltransferase 家族，是一種參與第二相生物轉化的酵素，主要處理脂溶性底物。它可作用於內源性化合物，也可代謝藥物與外來化合物，涉及的底物類別包括類固醇、維生素 A 代謝物、膽酸相關分子及多種藥物。蛋白質長 529 個胺基酸，具有 N 端訊號區段，並在 C 端附近有一段螺旋型跨膜區；註解將其定位為單次跨膜蛋白。這些家族與結構特徵提供了認識 UGT2B7 的基本背景，其底物轉化方式與生物學作用如下文所述。
基因異名與舊稱
異名取自 HGNC，可能包含歷史名稱；蛋白質名稱以 UniProt 註解為準。
染色體位置與基因結構
查看實際轉錄本與 exon 註解
| Transcript | Genomic coordinates | Exons |
|---|---|---|
| ENST00000305231 ★ | 69,096,474–69,112,987 | 6 |
| ENST00000502942 | 69,051,363–69,108,227 | 6 |
| ENST00000508661 | 69,096,455–69,112,987 | 5 |
| ENST00000622664 | 69,096,455–69,112,987 | 4 |
| ENST00000868341 | 69,096,455–69,112,987 | 7 |
| ENST00000868343 | 69,096,455–69,112,987 | 7 |
| ENST00000868344 | 69,096,455–69,112,987 | 6 |
| ENST00000868345 | 69,096,455–69,112,987 | 7 |
| ENST00000993083 | 69,096,455–69,112,836 | 6 |
| ENST00001012212 | 69,096,455–69,112,984 | 7 |
| ENST00001098428 | 69,096,455–69,112,987 | 7 |
| ENST00001108324 | 69,096,455–69,101,647 | 3 |
顯示 12/20 個蛋白質編碼轉錄本；canonical 優先。
帶型與著絲點依 Ensembl 座標繪製；核染色體長度以 GRCh38 第 1 號染色體為共同尺度。黃色標記表示本基因位置，細小區間加粗以利辨識；實際基因長度與 exon 見下方資料。
分子功能與生物學過程
UGT2B7 催化葡萄醣醛酸化反應：將葡萄醣醛酸接到脂溶性受質上，形成葡萄醣醛酸結合物。這種修飾可提高代謝物的水溶性，促進其經尿液或膽汁排出，因此參與藥物、外來化合物與內源性物質的清除及解毒。其反應的一般形式是以 UDP-alpha-D-glucuronate 作為葡萄醣醛酸供體，產生結合物及 UDP；不同受質可在不同位置形成產物。
此酵素可轉化多種內源性類固醇，包括雄性素 epitestosterone，以及雌激素 estradiol、epiestradiol、estriol 和 catechol estrogens。所記錄的反應涵蓋不同雌激素形式與結合位置，例如 estradiol 的 17-O 位，以及羥基化雌激素的其他位置。UGT2B7 也參與 retinoic acid 的葡萄醣醛酸化；retinoic acid 是維生素 A 的主要代謝物，與細胞凋亡、生長、分化及胚胎發育相關，因此其代謝可調節 retinoic acid 的含量。
在膽汁酸代謝方面，UGT2B7 可催化膽酸底物的葡萄醣醛酸化，參與膽汁酸解毒；膽汁酸本身是協助膳食脂質吸收的天然界面活性物質。它也作用於 arachidonic acid 及其衍生的 eicosanoids，包括 15-HETE、20-HETE、PGE2、PGB1，以及 F2-isoprostanes，例如 8-iso-PGF2alpha 和 5-epi-5-F2t-IsoP。此外，該酵素可在 ferulic acid 的酚基或羧酸基位置催化葡萄醣醛酸化。
UGT2B7 的藥物底物包括免疫抑制劑 mycophenolate，以及 losartan、candesartan 和 zolarsartan 等 AGTR1 angiotensin receptor antagonist；這些藥物可抑制 angiotensin II 的作用。另有反應註解記錄其可催化 sterol 形成 sterol 3-beta-D-glucoside。這些不同類型的轉化共同說明，UGT2B7 的作用涵蓋多種內源性分子與藥物的代謝，而非限於單一底物類別。
Promoter 與基因調控
>UGT2B7 ENST00000305231 GRCh38 chr4:69095474-69096574 strand=1 5′→3′ 相對 TSS：-1000 到 +100 bp；1101 bp 依轉錄本 TSS 擷取的基因組序列；TSS = 0，兩端包含，未驗證為 promoter GGACCTGAAGGAATACCTCAAAAGGAAAGTTGATCATTTCATAATGTTTAAGTTAATATTTATAGAAGGA TTAAGAGGAACTATAGTCTTGTAACAGGGTCTGCATAATTCTAGGACAACAGCCAAATAACTGTGAGGAA GTGAGTCGGAGAACAAGCTAACCTAATGATTAATGCTGAATGTACTACAAGCTTGGTTTACTTTTCTCTT TTTCTTTCTTTATCTTTGATTACTTTAACAAAGTTTAAAAAGATAGTGTCATCTTGAAACTCTCAATATC TTACATGATGGTTGTAAGAATCAACATGTATACGCTATATCATAAATGAACCTTTAAAATATTATGTTAC ATAAAAGAAGCCAGTCACAAAATACCACATATTGTATGATTCTATGCATTAAAAATTGTCCAGAATAGGC AAATCTATAGAGATAGAAATTCAATTAGCAATTACCTAGGACAGGGGAAATGCAGAAACTAGGGGTGGAG AGAAAAAGGCTAAGGACTATAGGGCTTATTTTGGGGAGATAAAAGGGCTCTCCAACTGATTGTTATGGTA GATGCACAATTCTGTGAATATACTATGAAACATTAAATTTTACACAATAATTGATAAATAGTATGATATT TAAATTACATGTCAACAAAGTTTACAAAAATATGTGGACCATGTTTAGTCATTTAATCTTTAGTTTTGTG TCAAATGGACTGCAGAAACAAGATCTGTCACTGCTACTGTTCTGGACACTCTTCTAAAATATATTGCATA AGACAGATGGCATGTCCATACAAGATCCTTGATATTAGCTGAAGGATAGCACTCATAAACATAAAAGGGA AATTAATCACATCTGTGTGAACAGATCATTTACCTTCATTTGTCTCTTTGCCATCCACATGCTCAGACTG TTGATTTAATGATATTGTATGTACTTTGACTTATAAGGGTTACATTTTAACTTCTTGGCTAATTTATCTT TGGACATAACCATGAGAAATGACAGAAAGGAACAGCAACTGGAAAACAAGCATTGCATTGCACCAGGATG TCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTT
EPDnew 實驗支持 promoter／TSS · 2 筆
| EPDnew ID | TSS（1-based） | 股向 | 來源顯示區間 |
|---|---|---|---|
| UGT2B7_2 ↗ | 4:69,051,233 | 正股 | 69,051,184–69,051,243 |
| UGT2B7_1 ↗ | 4:69,096,474 | 正股 | 69,096,425–69,096,484 |
EPDnew human v006 · UCSC hg38，GRCh38/hg38，透過 UCSC 取得。TSS 具有 CAGE／RAMPAGE 等實驗資料支持；任意擷取的上下游區間仍需另行判讀調控功能，不能視為整段皆經功能驗證。
EPD 封存狀態 ↗ · UCSC 資料說明 ↗ · EPD team, SIB Swiss Institute of Bioinformatics; UCSC Genome Browser · CC BY 4.0
查看已取得的調控／motif 註解
ENSR4_932FG2 · enhancer · 69092166–69092542 · regulatory
ENSR4_BHP8G · enhancer · 69095213–69095797 · regulatory
ENSR4_932FH6 · promoter · 69096161–69096529 · regulatory
· motif · 69092426–69092439 · motif
· motif · 69092426–69092439 · motif
· motif · 69095302–69095316 · motif
· motif · 69095350–69095361 · motif
· motif · 69095354–69095368 · motif
· motif · 69095354–69095368 · motif
· motif · 69096401–69096416 · motif
· motif · 69096952–69096965 · motif
· motif · 69096952–69096965 · motif
蛋白質結構域與序列
參考蛋白質長度：529 aa
UDP-glucuronosyltransferase 2B7 長 529 個胺基酸，屬於 UDP-glycosyltransferase 家族。序列註解標示其第 1–23 位為訊號區段，第 493–509 位為螺旋型跨膜區。
蛋白質三維結構
細胞內定位
UGT2B7 定位於內質網膜，並註解為單次跨膜蛋白。 來源未提供其他條件下的定位變化或異構型差異。
深綠色圓點：來源記載的蛋白質定位；數量不表示含量。
動物細胞結構示意；器官大小與數量不按比例。點選細胞構造可查看定位註解。
交互作用與訊號網絡
拖曳節點後放開可帶動位置變化；點選夥伴查看證據。位置與連線長度不代表結合強度，圖中未推定夥伴彼此之間的關係。
疾病與遺傳關聯
Contextual Functional Evidence Matrix
矩陣以「功能主張」為列，以細胞情境、干預條件、量測結果與證據來源為欄，方便比較同一功能在不同條件下的支持情形。只有含情境與實驗資訊的紀錄會列入矩陣；一般功能註解另列於下方。
功能註解總覽 · 32 筆
| 功能面向 | 功能敘述 | 證據類型 | 可查核來源 |
|---|---|---|---|
| 功能 | UGT2B7 進行第二相生物轉化，將葡萄醣醛酸接合至脂溶性受質，提高代謝物水溶性並促進其由尿液或膽汁排出，參與藥物、外來化合物及內源性物質的清除與解毒。其受質涵蓋多種雄性素與雌激素、retinoic acid、膽酸、arachidonic acid 衍生的 eicosanoids、ferulic acid，以及 mycophenolate 和若干 AGTR1 angiotensin receptor antagonist。 | 含實驗來源 | 證據與來源UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGE2, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent PMID 10702251 ↗ · PMID 15231852 ↗ · PMID 15470161 ↗ · PMID 15472229 ↗ · PMID 17442341 ↗ · PMID 18674515 ↗ · PMID 18719240 ↗ · PMID 19022937 ↗ · PMID 21422672 ↗ · PMID 2159463 ↗ · PMID 23288867 ↗ · PMID 23756265 ↗ · PMID 26220143 ↗ · PMID 38211441 ↗ · PMID 9169006 ↗ |
| 分子活性 | glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+) | 含實驗來源 | 證據與來源glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+) PMID 10702251 ↗ · PMID 15231852 ↗ · PMID 15470161 ↗ · PMID 15472229 ↗ · PMID 17442341 ↗ · PMID 18674515 ↗ · PMID 18719240 ↗ · PMID 19022937 ↗ · PMID 21422672 ↗ · PMID 23288867 ↗ · PMID 23756265 ↗ · PMID 26220143 ↗ · PMID 38211441 ↗ |
| 分子活性 | a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+) | 含實驗來源 | |
| 分子活性 | 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+) PMID 18719240 ↗ · PMID 23288867 ↗ |
| 分子活性 | 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+) PMID 18719240 ↗ |
| 分子活性 | 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+) PMID 15472229 ↗ |
| 分子活性 | 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + UDP + H(+) PMID 15472229 ↗ |
| 分子活性 | 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + UDP + H(+) PMID 15472229 ↗ |
| 分子活性 | 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + UDP + H(+) PMID 26220143 ↗ |
| 分子活性 | 16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + UDP + H(+) PMID 23288867 ↗ |
| 分子活性 | 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + UDP + H(+) PMID 23288867 ↗ |
| 分子活性 | 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + UDP + H(+) PMID 23288867 ↗ |
| 分子活性 | 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + UDP + H(+) PMID 23288867 ↗ |
| 分子活性 | epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + UDP + H(+) PMID 19022937 ↗ |
| 分子活性 | hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP + H(+) PMID 23756265 ↗ |
| 分子活性 | hyocholate + UDP-alpha-D-glucuronate = hyocholate 6-O-(beta-D-glucuronate) + UDP + H(+) | 含實驗來源 | 證據與來源hyocholate + UDP-alpha-D-glucuronate = hyocholate 6-O-(beta-D-glucuronate) + UDP + H(+) PMID 23756265 ↗ |
| 分子活性 | all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP | 含實驗來源 | 證據與來源all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP PMID 10702251 ↗ |
| 分子活性 | all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + UDP + H(+) | 含實驗來源 | 證據與來源all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + UDP + H(+) PMID 10702251 ↗ |
| 分子活性 | (E)-ferulate + UDP-alpha-D-glucuronate = (E)-ferulic acid beta-D-glucuronate ester + UDP | 含實驗來源 | 證據與來源(E)-ferulate + UDP-alpha-D-glucuronate = (E)-ferulic acid beta-D-glucuronate ester + UDP PMID 21422672 ↗ |
| 分子活性 | 8-iso-prostaglandin F2alpha + UDP-alpha-D-glucuronate = 8-iso-prostaglandin F2alpha-glucuronide + UDP + H(+) | 含實驗來源 | 證據與來源8-iso-prostaglandin F2alpha + UDP-alpha-D-glucuronate = 8-iso-prostaglandin F2alpha-glucuronide + UDP + H(+) PMID 38211441 ↗ |
| 分子活性 | 5-epi-5-F2t-IsoP + UDP-alpha-D-glucuronate = 5-epi-5-F2t-IsoP-glucuronide + UDP + H(+) | 含實驗來源 | 證據與來源5-epi-5-F2t-IsoP + UDP-alpha-D-glucuronate = 5-epi-5-F2t-IsoP-glucuronide + UDP + H(+) PMID 38211441 ↗ |
| 分子活性 | (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP | 含實驗來源 | 證據與來源(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP PMID 15231852 ↗ |
| 分子活性 | 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+) | 含實驗來源 | 證據與來源15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+) PMID 15231852 ↗ |
| 分子活性 | 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+) | 含實驗來源 | 證據與來源20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+) PMID 15231852 ↗ |
| 分子活性 | (E)-ferulate + UDP-alpha-D-glucuronate = (E)-4-O-(beta-D-glucuronosyl)-ferulate + UDP + H(+) | 含實驗來源 | 證據與來源(E)-ferulate + UDP-alpha-D-glucuronate = (E)-4-O-(beta-D-glucuronosyl)-ferulate + UDP + H(+) PMID 21422672 ↗ |
| 分子活性 | prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+) | 含實驗來源 | 證據與來源prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+) PMID 15231852 ↗ |
| 分子活性 | mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP | 含實驗來源 | 證據與來源mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP PMID 15470161 ↗ |
| 分子活性 | losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP | 含實驗來源 | |
| 分子活性 | candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP | 含實驗來源 | 證據與來源candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP PMID 18674515 ↗ |
| 分子活性 | candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP | 含實驗來源 | 證據與來源candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP PMID 18674515 ↗ |
| 分子活性 | zolasartan + UDP-alpha-D-glucuronate = zolarsartan O-beta-D-glucuronoside + UDP | 含實驗來源 | |
| 細胞定位 | UGT2B7 位於內質網膜，並被註解為單次跨膜蛋白；此定位描述未提供不同條件或異構型間的差異。 | 含實驗來源 |
核酸與蛋白質序列
GACAGAAAGGAACAGCAACTGGAAAACAAGCATTGCATTG40CACCAGGATGTCTGTGAAATGGACTTCAGTAATTTTGCTA80ATACAACTGAGCTTTTGCTTTAGCTCTGGGAATTGTGGAA120AGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAA160TATAAAGACAATCCTGGATGAGCTTATTCAGAGAGGTCAT200GAGGTGACTGTACTGGCATCTTCAGCTTCCATTCTTTTTG240ATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCC280CACATCTTTAACTAAAACTGAGTTGGAGAATTTCATCATG320CAACAGATTAAGAGATGGTCAGACCTTCCAAAAGATACAT360TTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAAT400ATTTGGTGACATAACTAGAAAGTTCTGTAAAGATGTAGTT440TCAAATAAGAAATTTATGAAAAAAGTACAAGAGTCAAGAT480TTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGA520GCTGCTGGCTGAGCTATTTAACATACCCTTTGTGTACAGT560CTCAGCTTCTCTCCTGGCTACACTTTTGAAAAGCATAGTG600GAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTAT640GTCAGAATTAACTGATCAAATGACTTTCATGGAGAGGGTA680AAAAATATGATCTATGTGCTTTACTTTGACTTTTGGTTCG720AAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGA760AGTTCTAGGAAGACCCACTACATTATCTGAGACAATGGGG800AAAGCTGACGTATGGCTTATTCGAAACTCCTGGAATTTTC840AGTTTCCATATCCACTCTTACCAAATGTTGATTTTGTTGG880AGGACTCCACTGCAAACCTGCCAAACCCCTGCCTAAGGAA920ATGGAAGACTTTGTACAGAGCTCTGGAGAAAATGGTGTTG960cDNA 使用 DNA 字母 T；mRNA 模式改以 U 顯示。轉錄本保留已註解的非編碼區，未另外加入 poly(A) 尾；非編碼 RNA 的參考轉錄本也可能仍需後續加工。數字為所選序列的 1-based 位置。長序列以黃色捲軸瀏覽，可複製或下載完整轉錄本與蛋白質；基因組 DNA 隨捲動取得所需範圍。