基因總覽
TRAF2 的正式名稱為 TNF receptor associated factor 2，是一種蛋白質編碼基因，產物屬於 TNF receptor-associated factor 家族。其蛋白質長 501 個胺基酸，帶有多個鋅指區域及 C 端 MATH 結構域，並含有與 BIRC2、BIRC3 交互作用相關的區域。這些結構特徵提供了辨識其蛋白質家族與分子組成的基本線索；TRAF2 的具體酵素作用及其在訊號調節中的角色，則見下方功能說明。
基因異名與舊稱
異名取自 HGNC，可能包含歷史名稱；蛋白質名稱以 UniProt 註解為準。
染色體位置與基因結構
查看實際轉錄本與 exon 註解
| Transcript | Genomic coordinates | Exons |
|---|---|---|
| ENST00000247668 ★ | 136,886,516–136,926,607 | 11 |
| ENST00000882553 | 136,881,903–136,929,221 | 12 |
| ENST00000419057 | 136,881,912–136,908,218 | 6 |
| ENST00000882552 | 136,881,913–136,929,221 | 12 |
| ENST00000882554 | 136,882,248–136,929,221 | 12 |
| ENST00000429509 | 136,886,065–136,909,971 | 6 |
| ENST00000850853 | 136,886,418–136,929,221 | 11 |
| ENST00000882556 | 136,886,418–136,929,221 | 11 |
| ENST00000882557 | 136,886,418–136,929,221 | 11 |
| ENST00000882558 | 136,886,418–136,929,221 | 11 |
| ENST00000882559 | 136,886,418–136,929,221 | 11 |
| ENST00000882560 | 136,886,418–136,929,221 | 13 |
顯示 12/57 個蛋白質編碼轉錄本；canonical 優先。
帶型與著絲點依 Ensembl 座標繪製；核染色體長度以 GRCh38 第 1 號染色體為共同尺度。黃色標記表示本基因位置，細小區間加粗以利辨識；實際基因長度與 exon 見下方資料。
分子功能與生物學過程
TRAF2 是 E3 ubiquitin-protein ligase，參與調節 NF-kappa-B 與 JNK 的活化，並在細胞存活和凋亡的調控中扮演重要角色。它可催化目標蛋白的 Lys-63 連結型泛素化，已列出的受質包括 BIRC3、IKBKE、MLST8、RIPK1 與 TICAM1。作為多種 E3 ubiquitin-protein ligase 複合體的重要成分，TRAF2 也能協助目標蛋白接近其他 E3 ubiquitin ligase，促進其泛素化。
TRAF2 對 BIRC2 和 BIRC3 蛋白量的調節，涉及抑制兩者的自體泛素化及後續降解；此作用不依賴 TRAF2 的 RING-type zinc finger domain。TRAF2 與 BIRC2 或 BIRC3 形成複合體時，還可促進 IKBKE 泛素化。它也參與 EIF2AK2/PKR 所介導的 NF-kappa-B 活化。
在 mTOR 調節方面，TRAF2 透過促進 MLST8 的 Lys-63 連結型泛素化，影響 mTORC1 與 mTORC2 的組裝：此修飾抑制 mTORC2 複合體形成，同時促進 mTORC1 組裝。這說明 TRAF2 的泛素化作用可對不同複合體的形成產生不同方向的影響。
此外，依相似性推定，TRAF2 是 IgM 轉換為 IgG 的正常抗體同種型轉換所必需的。此項功能註記帶有 By similarity 的證據限定，應與前述直接列出的泛素化及訊號調節作用區分看待。
Promoter 與基因調控
>TRAF2 ENST00000247668 GRCh38 chr9:136885516-136886616 strand=1 5′→3′ 相對 TSS：-1000 到 +100 bp；1101 bp 依轉錄本 TSS 擷取的基因組序列；TSS = 0，兩端包含，未驗證為 promoter TTGAGTGTCTGGAGGCCATAGGTTGTGTTTTCACTTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACAT GGTGAAACCTCGTCTCTATCAAAAATACAAACATTAGCCGGGCGTGATGGCGGGCGCCTGTAGTCCCAGC TACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGTCGAGATCGCG CCACTGAACTCCAGCCTGGGCGACAGAGTGAGCCTCCGTCTCAAAAAAAAAAATAAATAAAGTGCACAAC CCAGTAGATTAGCACACCGGCCATGTCGGGCGGCCGTCACCACTGTCCGGTTGCAGAGCATTACCTCACC CCAAAAGGAGACCCCATAGCCTTAATACCTTACTTAAGTGTGCAGTATTCTTTTAGTCCTGTTTCTCATA AATGTTACCCAAATTGAGGCGCCGCTCTGCGCCCGGCACCGGGGGAGGCGGAGGGACCCGCAGGTGTCGG GTAGGTGCGGCCGCCCCGCCAGGGCCCCGCGTCCCGCGCGCGACGCGCGCCTCGTGGGAACCGGTGTCGC CCGGCTTGGGCTCCCGGCTCACCTCTCGGGTGTGCGGCAGGGGTCTCCGCCCCGGGGCCACGGGAGGGGA AGCAAGGGCCTCGCTGTCTCGCCGCACCTGGGGAAGGGACCCAATTAGCGCGGACCCCACAGCGCAGCAC CTCACCAGCTCCCCGCACCAACGCCCCGGCGCGCTCTTTGAGGAAAAAGCAGAGGGCGACTTAGGTACCC ACGCCGTCTCAGCGCCGACCAATCGGCGCACGCTGCGGCTCCTGCGGGCTCGCTGGTTGGCTCCGGCGTC AGTCCGTCAGGCGCGCTCGGAGCGGGGCGTATCTGGCCAATGGCTCTCGCTACAGCTTCCTGAGGGCTGG CTGGTTGGCTCCCATGTCCGTCCGTCAGGCGCACGCGGCGGAGCGGCGGCGGCGGCGGCGGCGTTGGGGG CGGTAGCTGGGCGGGCCCTTAGTTCCGGGCGCGCTGCGACCGTTGGGTGAGGCGAGCGCGGGGTCGGGTG CGGGGTCGGGCGCGGGCGCGGGGTCGGGTGCGGGGTCGGGCGCGGGGTCGG
EPDnew 實驗支持 promoter／TSS · 2 筆
| EPDnew ID | TSS（1-based） | 股向 | 來源顯示區間 |
|---|---|---|---|
| TRAF2_2 ↗ | 9:136,881,912 | 正股 | 136,881,863–136,881,922 |
| TRAF2_1 ↗ | 9:136,886,516 | 正股 | 136,886,467–136,886,526 |
EPDnew human v006 · UCSC hg38，GRCh38/hg38，透過 UCSC 取得。TSS 具有 CAGE／RAMPAGE 等實驗資料支持；任意擷取的上下游區間仍需另行判讀調控功能，不能視為整段皆經功能驗證。
EPD 封存狀態 ↗ · UCSC 資料說明 ↗ · EPD team, SIB Swiss Institute of Bioinformatics; UCSC Genome Browser · CC BY 4.0
查看已取得的調控／motif 註解
ENSR9_CHKPR · enhancer · 136881577–136883123 · regulatory
ENSR9_CHKQ2 · enhancer · 136884532–136886240 · regulatory
ENSR9_6L4MN9 · CTCF_binding_site · 136884917–136884949 · regulatory
ENSR9_942BZB · promoter · 136886241–136886526 · regulatory
ENSR9_5377BKP · CTCF_binding_site · 136886257–136886278 · regulatory
ENSR9_CHKQ5 · enhancer · 136886527–136887744 · regulatory
ENSR9_5377BRG · CTCF_binding_site · 136887500–136887521 · regulatory
· motif · 136881563–136881578 · motif
· motif · 136881563–136881578 · motif
· motif · 136881645–136881656 · motif
· motif · 136881779–136881792 · motif
· motif · 136881779–136881792 · motif
· motif · 136882012–136882027 · motif
· motif · 136882041–136882054 · motif
· motif · 136882041–136882054 · motif
· motif · 136882042–136882055 · motif
· motif · 136882042–136882055 · motif
· motif · 136882205–136882218 · motif
· motif · 136882644–136882664 · motif
· motif · 136882676–136882692 · motif
· motif · 136882676–136882692 · motif
· motif · 136882711–136882719 · motif
· motif · 136882751–136882766 · motif
· motif · 136882927–136882936 · motif
· motif · 136884919–136884935 · motif
· motif · 136884930–136884946 · motif
· motif · 136885199–136885208 · motif
· motif · 136885994–136886003 · motif
· motif · 136886168–136886177 · motif
· motif · 136886259–136886275 · motif
· motif · 136886318–136886335 · motif
· motif · 136886465–136886478 · motif
· motif · 136886477–136886490 · motif
· motif · 136886515–136886524 · motif
· motif · 136886654–136886667 · motif
· motif · 136886660–136886673 · motif
· motif · 136886683–136886696 · motif
· motif · 136886854–136886867 · motif
· motif · 136886987–136886999 · motif
· motif · 136887390–136887402 · motif
· motif · 136887392–136887399 · motif
· motif · 136887453–136887468 · motif
· motif · 136887502–136887518 · motif
· motif · 136887691–136887704 · motif
· motif · 136888342–136888353 · motif
· motif · 136888382–136888393 · motif
· motif · 136890261–136890275 · motif
蛋白質結構域與序列
參考蛋白質長度：501 aa
TRAF2 蛋白長 501 個胺基酸，屬於 TNF receptor-associated factor 家族。其特徵包括 RING-type zinc finger、兩個 TRAF-type zinc finger，以及位於 C 端的 MATH domain。第 283–293 位胺基酸區段被註記為與 BIRC2、BIRC3 交互作用有關。
蛋白質三維結構
細胞內定位
TRAF2 的細胞內定位註記為細胞質。 此資料未提供不同刺激條件、異構型或定位變化的相關資訊。
深綠色圓點：來源記載的蛋白質定位；數量不表示含量。
動物細胞結構示意；器官大小與數量不按比例。點選細胞構造可查看定位註解。
交互作用與訊號網絡
拖曳節點後放開可帶動位置變化；點選夥伴查看證據。位置與連線長度不代表結合強度，圖中未推定夥伴彼此之間的關係。
更多交互作用夥伴 · 已取得 308 個夥伴
- AASDHPPTQ9NRN7 · UniProt INTERACTION · 7 experiments
- AFF4Q9UHB7 · UniProt INTERACTION · 3 experiments · 2 筆來源紀錄
- AGR2O95994 · UniProt INTERACTION · 3 experiments
- AKR1B15C9JRZ8-2 · UniProt INTERACTION · 3 experiments
- AMOTL2Q9Y2J4-4 · UniProt INTERACTION · 3 experiments
- ANKRD11X5D778 · UniProt INTERACTION · 4 experiments
- ANKRD36BP1Q96IX9 · UniProt INTERACTION · 4 experiments
- APBA1Q02410 · UniProt INTERACTION · 2 experiments
- APBA2Q99767 · UniProt INTERACTION · 2 experiments
- APPL1Q9UKG1 · UniProt INTERACTION · 3 experiments
- AQP1P29972 · UniProt INTERACTION · 3 experiments
- ARHGEF6Q15052 · UniProt INTERACTION · 3 experiments
- ARSJQ8N5N6 · UniProt INTERACTION · 3 experiments
- ASCC1Q8N9N2 · UniProt INTERACTION · 3 experiments · 2 筆來源紀錄
- ATOSBQ7L5A3 · UniProt INTERACTION · 3 experiments
- ATXN1P54253 · UniProt INTERACTION · 14 experiments
- AXIN1O15169 · UniProt INTERACTION · 3 experiments
- BAHD1Q8TBE0 · UniProt INTERACTION · 4 experiments
- BANPB4DE54 · UniProt INTERACTION · 3 experiments
- BANPQ8N9N5 · UniProt INTERACTION · 4 experiments · 3 筆來源紀錄
- BAZ2BQ9UIF8 · UniProt INTERACTION · 3 experiments
- BCL10O95999 · UniProt INTERACTION · 11 experiments
- BCL6P41182 · UniProt INTERACTION · 3 experiments
- BEX2Q9BXY8 · UniProt INTERACTION · 6 experiments
- BIRC2Q13490 · UniProt INTERACTION · 19 experiments
TRAF2 可形成同源三聚體，也可與 TRAF1 或 TRAF3 形成異源三聚體；含 RING-type 與第一個 TRAF-type zinc finger 的區域則可在體外形成同源二聚體。它與多種 TNF receptor 家族成員有交互作用，包括 TNFRSF1B/TNFR2 與 TNFRSF5/CD40。TNFRSF1A 受刺激時，TRAF2 可參與細胞膜上的 complex I；其後與 TRADD、RIPK1 一同離開受體，並在細胞質形成含 FADD、CASP8 的 complex II。這些複合體與細胞存活或凋亡相關，但不代表單一互作本身即可決定結果。
疾病與遺傳關聯
Contextual Functional Evidence Matrix
矩陣以「功能主張」為列，以細胞情境、干預條件、量測結果與證據來源為欄，方便比較同一功能在不同條件下的支持情形。只有含情境與實驗資訊的紀錄會列入矩陣；一般功能註解另列於下方。
功能註解總覽 · 5 筆
| 功能面向 | 功能敘述 | 證據類型 | 可查核來源 |
|---|---|---|---|
| 功能 | TRAF2 是 E3 ubiquitin-protein ligase，可調節 NF-kappa-B 與 JNK 活化，並參與細胞存活和凋亡的調控。它催化多種目標蛋白的 Lys-63 連結型泛素化，也能在 E3 ligase 複合體中促進受質接觸其他 E3 ligase。TRAF2 抑制 BIRC2、BIRC3 的自體泛素化與降解，此作用不依賴其 RING-type zinc finger domain；它亦參與 EIF2AK2/PKR 介導的 NF-kappa-B 活化、IKBKE 泛素化及 mTOR 複合體組裝調節。依相似性推定，TRAF2 也是 IgM 轉為 IgG 的正常抗體同種型轉換所必需。 | 含實驗來源 | 證據與來源E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex. Required for normal antibody isotype switching from IgM to IgG (By similarity) PMID 10346818 ↗ · PMID 11784851 ↗ · PMID 11907583 ↗ · PMID 12917689 ↗ · PMID 15121867 ↗ · PMID 15383523 ↗ · PMID 18981220 ↗ · PMID 19150425 ↗ · PMID 19506082 ↗ · PMID 19810754 ↗ · PMID 19918265 ↗ · PMID 19937093 ↗ · PMID 20047764 ↗ · PMID 20064526 ↗ · PMID 20385093 ↗ · PMID 20577214 ↗ · PMID 22212761 ↗ · PMID 23453969 ↗ · PMID 28489822 ↗ |
| 分子活性 | S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. | 含實驗來源 | 證據與來源S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. PMID 20577214 ↗ · PMID 28489822 ↗ |
| 分子活性 | TRAF2 的功能分類包括蛋白質修飾，具體涉及蛋白質泛素化。 | 資料庫紀錄 | |
| 交互作用 | TRAF2 可形成同源三聚體，或與 TRAF1、TRAF3 形成異源三聚體；特定含鋅指區域也能在體外形成同源二聚體。它與多種 TNF receptor 家族成員及訊號蛋白交互作用，並參與 TNFRSF1A 刺激後形成的膜上 complex I 與細胞質 complex II。來源亦記載其與多種泛素化、去泛素化及激酶相關蛋白的互作；部分互作可能促進或抑制 NF-kappa-B、JNK 等訊號，另有若干作用標示為推測或依相似性而來。 | 含實驗來源 | 證據與來源Homotrimer. Heterotrimer with TRAF1. Heterotrimer with TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2. Interacts with TNFRSF5/CD40. Interacts with TNFRSF4, TNFRSF7/CD27, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT and EDAR. Stimulation of TNF receptor TNFRSF1A leads to the formation of two distinct signaling complexes. Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival. Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis. Interacts with TRADD. Identified in a complex with TNFRSF1A, RIPK1 and IKBKB/IKK-beta. Interacts with RIPK2. Interacts with BIRC2 and BIRC3 UBA domain; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3 (By similarity). Interacts with BIRC2; the interaction promotes BIRC2 stability. Interaction with BIRC2 and/or BIRC3 is essential for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B (By similarity). Within complex I, phosphorylated TRAF2 interacts (via 'Lys-63'-linked polyubiquitin chains) with CHUCK/IKK-alpha, IKBKB/IKK-beta, IKBKG/IKK-gamma TAB2, TAB3 and TAK1 in response to TNF stimulation. Within complex I, interacts with UXT isoform 1 (via TPQE motif); the interaction prevents the recruitment of FADD and CASP8/caspase 8 to complex I. Forms a complex composed of TNFRSF8/CD30 or TNFRSF1B/TNFR2, and TRAF1, TRAF2 and E3 ligase TRAIP. Within the complex, interacts with TRAIP; the interaction inhibits TRAF2-mediated NF-kappa B activation. Component of a complex composed of TANK and TBK1. Interacts with TRPC4AP (By similarity). Interacts with MAP3K1/MEKK1, MAP3K5/ASK1 and MAP3K11/MLK3 in response to TNF stimulation; the interaction leads to JNK activation and interaction with MAP3K5 is inhibited by PRMT1. Component of a complex composed of MAP3K14/NIK BIRC3 and TRAF3; the interaction leads to BIRC2/3-mediated ubiquitination of TRAF3 upon CD40 engagement in a TRAF2-dependent manner (By similarity). Interacts with MAP3K14/NIK in response to TNF stimulation; the interaction leads to NF-kappa B activation. Interacts with PEG3; the interaction may promote TRAF2-mediated NF-kappa B activation (By similarity). Interacts with HIVEP3; the interaction may inhibit TNF-TRAF2-mediated NF-kappa B and JNK activation (By similarity). Interacts with TANK/ITRAF; the interaction prevents interaction between TNFRSF1B/TNFR2 and TRAF2. Interacts with deubiquitinating enzyme CYLD; the interaction results in the deubiquitination and inactivation of TRAF2. Interacts with SIAH2; the interaction leads to TRAF2 ubiquitination and degradation. Interacts with E2 conjugating enzyme UBE2N/Ubc13, E3 ligase ITCH and RNF11 in response to TNF stimulation (By similarity). Interacts with ubiquitin-editing enzyme TNFAIP3/A20 in response to TNF stimulation; the interaction promotes TRAF2 dissociation from UBE2N/Ubc13, ITCH, RNF11 and TAX1BP1 and prevents prolonged TRAF-2 ubiquitination (By similarity). Interacts with TAX1BP1 in response to TNF stimulation; the interaction promotes TRAF2 dissociation from UBE2N/Ubc13 and TNFAIP3/A20, and prevents prolonged TRAF-2 ubiquitination (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with deubiquitinating enzyme USP48. Interacts with PTPN2; probably involved in TNF-mediated signaling. Interacts with Toll-like receptor TLR4/3 adapter TICAM1/TRIF; the interaction may promote TICAM1 ubiquitination. Interacts with kinase/endoribonuclease ERN1/IRE1 and DAB2IP in response to ER stress; the interaction requires DAB2IP (By similarity). Interacts with ERN1/IRE1 and TAOK3 in response to ER stress; the interaction may promote TRAF2 phosphorylation. Interacts (via zinc fingers) with DAB2IP (via C-terminus PER domain)in response to TNF stimulation. Interacts with CASP8AP2/FLASH (By similarity). Interacts with NFATC2IP; the interaction may repress IL-4 production in T cells (By similarity). Interacts with kinase CDK9. Interacts with sphingosine kinase 1 SPHK1. Interacts with kinase TNIK. Interacts with TRAFD1 (By similarity). Interacts with DNA phosphodiesterase TDP2. Interacts with MAVS/IPS1. Interacts with CARD14. Interacts with Epstein-Barr virus LMP1/BNFL1. Interacts with GPS2 (By similarity). Interacts with XPNPEP3. Interacts with RIPK3. Interacts with RELL2. Interacts with LRRC19. Interacts with GAPDH; promoting TRAF2 ubiquitination. Interacts with STK4; interaction takes place following TNF activation and promotes recruitment of STK4 to TNF-R1 signaling complex PMID 10037686 ↗ · PMID 10206649 ↗ · PMID 10346818 ↗ · PMID 10411888 ↗ · PMID 10514511 ↗ · PMID 10521462 ↗ · PMID 10581243 ↗ · PMID 10764746 ↗ · PMID 10809768 ↗ · PMID 10880535 ↗ · PMID 10892748 ↗ · PMID 11035039 ↗ · PMID 11278723 ↗ · PMID 11907583 ↗ · PMID 12411493 ↗ · PMID 12917691 ↗ · PMID 15121867 ↗ · PMID 15310755 ↗ · PMID 15383523 ↗ · PMID 15696169 ↗ · PMID 16153868 ↗ · PMID 16214042 ↗ · PMID 17389591 ↗ · PMID 18981220 ↗ · PMID 19150425 ↗ · PMID 19506082 ↗ · PMID 19810754 ↗ · PMID 19918265 ↗ · PMID 19969290 ↗ |
| 細胞定位 | TRAF2 的細胞內定位註記為細胞質。 | 含實驗來源 |
核酸與蛋白質序列
AGTTCCGGGCGCGCTGCGACCGTTGGGGCTTTGTTCGCGG40GGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCC80TGGCTCCCTGGAGTTGCTACAGCCCGGCTTCTCCAAGACC120CTCCTGGGGACCAAGCTGGAAGCCAAGTACCTGTGCTCCG160CCTGCAGAAACGTCCTCCGCAGGCCCTTCCAGGCGCAGTG200TGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTC240AGCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAGG280GCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTC320GGCCTTCCCAGATAATGCTGCCCGCAGGGAGGTGGAGAGC360CTGCCGGCCGTCTGTCCCAGTGATGGATGCACCTGGAAGG400GGACCCTGAAAGAATACGAGAGCTGCCACGAAGGCCGCTG440CCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTG480GTCCGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGT520GCCCGGAGAGAAGCCTGAGCTGCCGGCATTGCCGGGCACC560CTGCTGCGGAGCAGACGTGAAGGCGCACCACGAGGTCTGC600CCCAAGTTCCCCTTAACTTGTGACGGCTGCGGCAAGAAGA640AGATCCCCCGGGAGAAGTTTCAGGACCACGTCAAGACTTG680TGGCAAGTGTCGAGTCCCTTGCAGATTCCACGCCATCGGC720TGCCTCGAGACGGTAGAGGGTGAGAAACAGCAGGAGCACG760AGGTGCAGTGGCTGCGGGAGCACCTGGCCATGCTACTGAG800CTCGGTGCTGGAGGCAAAGCCCCTCTTGGGAGACCAGAGC840CACGCGGGGTCAGAGCTCCTGCAGAGGTGCGAGAGCCTGG880AGAAGAAGACGGCCACTTTTGAGAACATTGTCTGCGTCCT920GAACCGGGAGGTGGAGAGGGTGGCCATGACTGCCGAGGCC960cDNA 使用 DNA 字母 T；mRNA 模式改以 U 顯示。轉錄本保留已註解的非編碼區，未另外加入 poly(A) 尾；非編碼 RNA 的參考轉錄本也可能仍需後續加工。數字為所選序列的 1-based 位置。長序列以黃色捲軸瀏覽，可複製或下載完整轉錄本與蛋白質；基因組 DNA 隨捲動取得所需範圍。