基因總覽
SYK（spleen associated tyrosine kinase）是蛋白質編碼基因，產物屬於蛋白激酶超家族中的酪胺酸蛋白激酶，並歸入 SYK/ZAP-70 亞家族。其蛋白質為非受體型激酶，具有兩個 SH2 結構域與一個蛋白激酶結構域，整體架構適合接收受體相關訊號並傳遞至細胞內。SYK 的作用不限於免疫細胞：來源指出它參與先天性與適應性免疫、細胞黏附、破骨細胞成熟、血小板活化及血管發育。其訊號功能可由多種跨膜受體引發，其中包括 B 細胞受體等免疫受體。
基因異名與舊稱
異名取自 HGNC，可能包含歷史名稱；蛋白質名稱以 UniProt 註解為準。
染色體位置與基因結構
查看實際轉錄本與 exon 註解
| Transcript | Genomic coordinates | Exons |
|---|---|---|
| ENST00000375754 ★ | 90,801,819–90,898,549 | 14 |
| ENST00000375751 | 90,801,579–90,898,549 | 13 |
| ENST00000865872 | 90,801,579–90,898,549 | 14 |
| ENST00000865875 | 90,801,579–90,898,549 | 15 |
| ENST00000865878 | 90,801,579–90,898,549 | 14 |
| ENST00000970482 | 90,801,579–90,898,549 | 13 |
| ENST00000970483 | 90,801,579–90,898,549 | 15 |
| ENST00001112793 | 90,801,579–90,879,114 | 11 |
| ENST00001137269 | 90,801,579–90,898,549 | 14 |
| ENST00000865873 | 90,801,743–90,898,549 | 15 |
| ENST00000865874 | 90,801,743–90,898,549 | 13 |
| ENST00000865876 | 90,801,743–90,898,549 | 14 |
顯示 12/19 個蛋白質編碼轉錄本；canonical 優先。
帶型與著絲點依 Ensembl 座標繪製；核染色體長度以 GRCh38 第 1 號染色體為共同尺度。黃色標記表示本基因位置，細小區間加粗以利辨識；實際基因長度與 exon 見下方資料。
分子功能與生物學過程
SYK 是多種跨膜受體下游的非受體型酪胺酸激酶。受體活化後，SYK 常透過自身 SH2 結構域辨識受體上已磷酸化的 ITAM，聚集於細胞膜並形成訊號複合體；也可能由帶有 ITAM 或部分 hemITAM 的接頭蛋白間接連接。ITAM 通常由 SRC 家族激酶在受體受刺激後磷酸化，但較少見時，SYK 訊號也可能不依賴 ITAM。SYK 可催化蛋白質酪胺酸磷酸化，並直接磷酸化多種下游效應分子，包括 DEPTOR、MYO1F、VAV1、PLCG1、PI-3-kinase、LCP2 與 BLNK。
在適應性免疫中，SYK 是 B 細胞受體（BCR）訊號的重要成員，並被認為對 B 細胞成熟必不可少，作用時點很可能位於 pro-B 至 pre-B 細胞階段。BCR 受刺激後，SYK 磷酸化並活化接頭蛋白 BLNK，使受體訊號連接至其他接頭蛋白與效應分子；它也可活化 PLCG1 與 PKC 訊號路徑，並依相似性資料調控 BTK 活性。SYK 亦參與 T 細胞受體訊號。
在先天免疫中，SYK 參與對真菌、細菌與病毒病原體的反應。例如膜上 lectin CLEC7A 受到真菌蛋白刺激時，可與 SYK 共同促使免疫細胞產生 ROS；SYK 也參與 inflammasome 活化，以及病原體存在時由 NF-kappa-B 介導的趨化因子與細胞激素轉錄。它可透過 MAPK 訊號級聯調節嗜中性球脫顆粒與吞噬作用，且對 IL15 刺激嗜中性球吞噬是必要的。來源另指出，SYK 參與細胞壞死刺激下的樹突細胞活化、肥大細胞活化，以及嗜鹼性球中的 IL3 訊號。
SYK 也將細胞黏附受體的訊號傳入細胞內，參與整合素介導的嗜中性球與巨噬細胞活化，以及 SELPG 相關的白血球募集。非免疫相關作用包括血管發育中可能調節血液與淋巴管分隔，以及破骨細胞發育與功能。血小板方面，SYK 參與膠原誘發的活化，促進 PLCG2 磷酸化與活化；它也可由 CLEC1B 或受纖維蛋白原刺激的 ITGB3 活化，並參與血小板黏附。另有資料指出，SYK 透過磷酸化 MYO1F，正向調節 cGAS-STING 訊號，促進 CGAS 定位至質膜並活化。
Promoter 與基因調控
>SYK ENST00000375754 GRCh38 chr9:90800819-90801919 strand=1 5′→3′ 相對 TSS：-1000 到 +100 bp；1101 bp 依轉錄本 TSS 擷取的基因組序列；TSS = 0，兩端包含，未驗證為 promoter TTCTGCTGAAGTTTTCTTTTAACAGGTTTAGAAAAAATAATGGCAAAAATGAATGAAAATCCAATAACCC TGGAAGCAGAAAAGGCTGGGGGCTCCAATAAGTGTAAATAGTCCCATCCCTATATTTTCTCCATGGCAAT TACAATCCAGCACATTATATATATATTTTTTTGCTTCTCGCATTTTGGCTTAGGGTAAAGCTTTTTAAAA CAGGCACTGCCAACCAGTGTTATCAAGAAGGTCTGGATGCCGTTTTGTGGGAACATTTTAAAGAGGAATG TCCAAAAGGAAAAGGGGGATGGGTTGGGAGAAGGGTATCAGGCGGGTATCTCAAAACCATTCTTAGGGCT ATAGGTTTAATTTATTTGGTTGTGGACGTCAGAGCCGTCATGGTAAGAAGGAAGCAAAGCCTTTTGTAAT AATTAAAGCCTTCAGAAGCAGCGTGCCCCATTGCCCACTAGTGCGCCGTGAAGTCTGGTGTTCACCTACA GGGTCCCTCTCAGCACTGCCCAGGCCTCCCGAGTGCTCCAGCACAGTAGCTTGGAGCTTGTTGGTTTGGT GACCAAGATACACTCCAGGGAATATGCCATGCAGTGGAGTCTCTTCCCCGGCACTGCATAGCAAAAGGAA AGGGCCGCTGGGTGTCTGTGGGTCCTGGGCAGTCACAGAAGCCACCGCGCTGGCGGGGAGGAGGGGGACC GATGCGGTCCATGTCCCGGGCAGCCCCACCTTCTCTGCCTGCGAAGGGCCCTTGTCCGGCGGGAGGAGAG AGGCGCGCCCCACCCGGGCTCCTCTACACCTGCCGCCGCCTGGGCCGATTCCGCGGGCCTCGCCCGGCGC TTCAGCCGATTCCCGCCCAGCTCCGGGCTCATGGGCGCGGTCAGCAGGGCGGGCCAGGGCGGCGGGGCGC GACACTGGGAGGAAGTGCGGGCCGCCTGCCCGGGCGCGTTAAGGAAGTTGCCCAAAATGAGGAAGAGCCG CGGGCCCGGCGGCTGAGGCCACCCCGGCGGCGGCTGGAGAGCGAGGAGGAGCGGGTGGCCCCGCGCTGCG CCCGCCCTCGCCTCACCTGGCGCAGGTAGGTGTGGCCGCGTCCCCTACCCG
EPDnew 實驗支持 promoter／TSS · 2 筆
| EPDnew ID | TSS（1-based） | 股向 | 來源顯示區間 |
|---|---|---|---|
| SYK_1 ↗ | 9:90,801,819 | 正股 | 90,801,770–90,801,829 |
| SYK_2 ↗ | 9:90,827,423 | 正股 | 90,827,374–90,827,433 |
EPDnew human v006 · UCSC hg38，GRCh38/hg38，透過 UCSC 取得。TSS 具有 CAGE／RAMPAGE 等實驗資料支持；任意擷取的上下游區間仍需另行判讀調控功能，不能視為整段皆經功能驗證。
EPD 封存狀態 ↗ · UCSC 資料說明 ↗ · EPD team, SIB Swiss Institute of Bioinformatics; UCSC Genome Browser · CC BY 4.0
查看已取得的調控／motif 註解
ENSR9_93C347 · enhancer · 90800094–90800414 · regulatory
ENSR9_BN2JR · promoter · 90801297–90801937 · regulatory
ENSR9_CC29G · enhancer · 90801938–90803051 · regulatory
ENSR9_BN2K6 · enhancer · 90803803–90804388 · regulatory
ENSR9_93C35G · promoter · 90804389–90804650 · regulatory
ENSR9_BN2KC · enhancer · 90805069–90805667 · regulatory
· motif · 90800270–90800281 · motif
· motif · 90800688–90800701 · motif
· motif · 90801613–90801622 · motif
· motif · 90801782–90801795 · motif
· motif · 90802127–90802140 · motif
· motif · 90802134–90802141 · motif
· motif · 90802180–90802193 · motif
· motif · 90802180–90802193 · motif
· motif · 90802192–90802209 · motif
· motif · 90804139–90804151 · motif
· motif · 90805792–90805805 · motif
蛋白質結構域與序列
參考蛋白質長度：635 aa
SYK 蛋白長 635 個胺基酸，屬於蛋白激酶超家族的酪胺酸蛋白激酶，並歸入 SYK/ZAP-70 亞家族。蛋白質含兩個 SH2 結構域（第 15–107 與 168–259 位）及一個蛋白激酶結構域（第 371–631 位）；兩者之間分別為 Interdomain A（第 108–167 位）與 Interdomain B（第 260–370 位）。
蛋白質三維結構
細胞內定位
SYK 位於細胞膜與細胞質溶膠。 來源未提供定位隨刺激、條件或異構型而改變的資訊。
深綠色圓點：來源記載的蛋白質定位；數量不表示含量。
動物細胞結構示意；器官大小與數量不按比例。點選細胞構造可查看定位註解。
交互作用與訊號網絡
拖曳節點後放開可帶動位置變化；點選夥伴查看證據。位置與連線長度不代表結合強度，圖中未推定夥伴彼此之間的關係。
更多交互作用夥伴 · 已取得 37 個夥伴
- APPP05067 · UniProt INTERACTION · 3 experiments · 2 筆來源紀錄
- CBLP22681 · UniProt INTERACTION · 2 experiments
- CD22P20273 · UniProt INTERACTION · 4 experiments
- CD37P11049 · UniProt INTERACTION · 3 experiments
- CD3EP07766 · UniProt INTERACTION · 6 experiments
- CLEC7AQ9BXN2 · UniProt INTERACTION · 2 experiments
- EGFRP00533 · UniProt INTERACTION · 7 experiments
- ERBB2P04626 · UniProt INTERACTION · 7 experiments
- ERBB3P21860 · UniProt INTERACTION · 6 experiments
- FCER1GP30273 · UniProt INTERACTION · 2 experiments
- FLT3P36888 · UniProt INTERACTION · 22 experiments
- GAB1Q13480 · UniProt INTERACTION · 4 experiments
- LCKP06239 · UniProt INTERACTION · 7 experiments
- METP08581 · UniProt INTERACTION · 3 experiments
- PLCG1P19174 · UniProt INTERACTION · 4 experiments
- PYCARDQ9ULZ3 · UniProt INTERACTION · 4 experiments
- SH2D2AQ9NP31 · UniProt INTERACTION · 3 experiments
- STAT3P40763 · UniProt INTERACTION · 10 experiments
- TENT5AQ96IP4 · UniProt INTERACTION · 3 experiments
- TERF1P54274 · UniProt INTERACTION · 2 experiments
- UBASH3BQ8TF42 · UniProt INTERACTION · 2 experiments
- USP25Q9UHP3 · UniProt INTERACTION · 8 experiments
- A2MP01023 · UniProt INTERACTION · 3 experiments
- APLP2Q06481-5 · UniProt INTERACTION · 3 experiments
- BLMHQ13867 · UniProt INTERACTION · 3 experiments
SYK 透過 SH2 結構域與 CD79A、FCER1G、TYROBP 等蛋白上的磷酸化 ITAM 結合；與 CD79A 的交互作用可促進 SYK 自體磷酸化及活化。它也與多種訊號蛋白互作，例如在 BCR 活化後磷酸化 VAV1，並與 BLNK 連結。另有功能性關係包括與 FLNA 互作以協助其停靠於質膜，以及與 MPL/TPOR 互作並負向調節 THPO 介導的 ERK1/2 訊號。微生物感染時，SYK 亦與 Epstein-Barr virus LMP2A 互作。
疾病與遺傳關聯
SYK 基因變異與常染色體顯性遺傳的 Immunodeficiency 82 with systemic inflammation（IMD82）相關。此病通常於幼年起病，特徵包括反覆感染及多器官發炎，可表現為結腸炎、肝炎、關節炎與皮膚炎；患者也較易在成年後發展為淋巴瘤。嚴重程度不一。來源將此病歸因於影響該基因的變異。
Contextual Functional Evidence Matrix
矩陣以「功能主張」為列，以細胞情境、干預條件、量測結果與證據來源為欄，方便比較同一功能在不同條件下的支持情形。只有含情境與實驗資訊的紀錄會列入矩陣；一般功能註解另列於下方。
功能註解總覽 · 6 筆
| 功能面向 | 功能敘述 | 證據類型 | 可查核來源 |
|---|---|---|---|
| 功能 | SYK 是非受體型酪胺酸激酶，傳遞多種跨膜受體（包括 B 細胞受體）的下游訊號，參與先天性與適應性免疫、細胞黏附、破骨細胞成熟、血小板活化及血管發育。它通常藉 SH2 結構域辨識受體磷酸化 ITAM，亦可透過含 ITAM 或部分 hemITAM 的接頭蛋白間接連接；ITAM 多由 SRC 家族激酶磷酸化，少數情況下訊號可不依賴 ITAM。SYK 磷酸化多種效應分子，並參與 B、T 細胞受體訊號、病原體防禦、吞噬與發炎反應，以及黏附、血管、破骨細胞和血小板相關過程；其亦可促進 cGAS-STING 訊號。 | 含實驗來源 | 證據與來源Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, MYO1F, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling (By similarity). In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). Acts as a positive regulator of cGAS-STING signaling by mediating phosphorylation of MYO1F, thereby promoting plasma membrane localization and activation of CGAS PMID 12387735 ↗ · PMID 12456653 ↗ · PMID 15123770 ↗ · PMID 15388330 ↗ · PMID 18369315 ↗ · PMID 19909739 ↗ · PMID 20154219 ↗ · PMID 33782605 ↗ · PMID 34634301 ↗ · PMID 39694035 ↗ · PMID 8657103 ↗ · PMID 9535867 ↗ · PMID 9698567 ↗ |
| 分子活性 | L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) | 含實驗來源 | 證據與來源L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) PMID 33782605 ↗ · PMID 34634301 ↗ · PMID 39694035 ↗ |
| 交互作用 | SYK 與多種受體、接頭蛋白及訊號分子互作，部分作用依賴其 SH2 結構域辨識磷酸化 ITAM 或其他蛋白區段。互作可促進 SYK 活化、自體磷酸化或下游蛋白磷酸化，也可能調節肥大細胞、嗜中性球、巨噬細胞、嗜鹼性球與血小板功能。另有互作負向調節 SYK 或相關訊號，例如 YWHAG 降低 BCR 誘發的膜轉位與活化；CEACAM1 相關複合體可招募 PTPN6 去磷酸化 SYK，降低 ROS、溶酶體破壞及 inflammasome 活性。若干作用標示為相似性推論或可能功能。 | 含實驗來源 | 證據與來源Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By similarity). Interacts with FCRL3. Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interaction with FCER1G in basophils triggers IL3-induced IL4 production (By similarity). Interacts with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels. Interacts (via SH2 domains) with CLEC1B (dimer). Interacts with CLEC7A; participates in leukocyte activation in presence of fungal pathogens. Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment. Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK. Interacts (via SH2 domains) with GCSAM; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity. Interacts with TNS2; leading to the phosphorylation of SYK. Interacts with FLNA (via filamin repeat 5); docks SYK to the plasma membrane. Interacts with CEACAM1; lipopolysaccharide activated neutrophils induce phosphorylation of SYK resulting in the formation of a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, leading to a reduction of the inflammasome activity (By similarity). Interacts (via SH2 domains) with CEACAM20 (phosphorylated form); the interaction further enhances CEACAM20 phosphorylation (By similarity). Interacts with IL15RA. Interacts with MPL/TPOR; this interaction negatively regulates THPO-mediated ERK1/2 signaling PMID 10449770 ↗ · PMID 11162587 ↗ · PMID 11940607 ↗ · PMID 12387735 ↗ · PMID 15123770 ↗ · PMID 18369315 ↗ · PMID 19843936 ↗ · PMID 19909739 ↗ · PMID 20154219 ↗ · PMID 20713593 ↗ · PMID 21469132 ↗ · PMID 22019427 ↗ · PMID 23299888 ↗ · PMID 24607955 ↗ · PMID 8657103 ↗ · PMID 8986718 ↗ · PMID 9535867 ↗ · PMID 9698567 ↗ · PMID 9857068 ↗ |
| 交互作用 | 在微生物感染情境中，SYK 與 Epstein-Barr virus LMP2A 互作。 | 含實驗來源 | |
| 細胞定位 | SYK 的定位註記為細胞膜及細胞質溶膠。 | 推論支持 | |
| 疾病關聯 | SYK 基因變異與 Immunodeficiency 82 with systemic inflammation（IMD82）相關，此病為常染色體顯性遺傳疾病，通常幼年起病。患者有反覆感染及多器官發炎，可能出現結腸炎、肝炎、關節炎與皮膚炎，且較易於成年後發展淋巴瘤；疾病嚴重程度不一。來源指出致病原因為影響該基因的變異。 | 含實驗來源 | 證據與來源Immunodeficiency 82 with systemic inflammation IMD82 An autosomal dominant immunologic disorder with onset in early childhood. It is characterized by recurrent infections with various organisms, and multi-organ inflammation that manifests as colitis, hepatitis, arthritis and dermatitis. Patients have a propensity for the development of lymphoma, usually in adulthood. Disease severity is variable. The disease is caused by variants affecting the gene represented in this entry MIM: 619381 PMID 33782605 ↗ |
核酸與蛋白質序列
ACCCCGGCGGCGGCTGGAGAGCGAGGAGGAGCGGGTGGCC40CCGCGCTGCGCCCGCCCTCGCCTCACCTGGCGCAGGTGGA80CACCTGCGCAGGTGTGTGCCCTCCGGCCCCTGAAGCATGG120CCAGCAGCGGCATGGCTGACAGCGCCAACCACCTGCCCTT160CTTTTTCGGCAACATCACCCGGGAGGAGGCAGAAGATTAC200CTGGTCCAGGGGGGCATGAGTGATGGGCTTTATTTGCTGC240GCCAGAGCCGCAACTACCTGGGTGGCTTCGCCCTGTCCGT280GGCCCACGGGAGGAAGGCACACCACTACACCATCGAGCGG320GAGCTGAATGGCACCTACGCCATCGCCGGTGGCAGGACCC360ATGCCAGCCCCGCCGACCTCTGCCACTACCACTCCCAGGA400GTCTGATGGCCTGGTCTGCCTCCTCAAGAAGCCCTTCAAC440CGGCCCCAAGGGGTGCAGCCCAAGACTGGGCCCTTTGAGG480ATTTGAAGGAAAACCTCATCAGGGAATATGTGAAGCAGAC520ATGGAACCTGCAGGGTCAGGCTCTGGAGCAGGCCATCATC560AGTCAGAAGCCTCAGCTGGAGAAGCTGATCGCTACCACAG600CCCATGAAAAAATGCCTTGGTTCCATGGAAAAATCTCTCG640GGAAGAATCTGAGCAAATTGTCCTGATAGGATCAAAGACA680AATGGAAAGTTCCTGATCCGAGCCAGAGACAACAACGGCT720CCTACGCCCTGTGCCTGCTGCACGAAGGGAAGGTGCTGCA760CTATCGCATCGACAAAGACAAGACAGGGAAGCTCTCCATC800CCCGAGGGAAAGAAGTTCGACACGCTCTGGCAGCTAGTCG840AGCATTATTCTTATAAAGCAGATGGTTTGTTAAGAGTTCT880TACTGTCCCATGTCAAAAAATCGGCACACAGGGAAATGTT920AATTTTGGAGGCCGTCCACAACTTCCAGGTTCCCATCCTG960cDNA 使用 DNA 字母 T；mRNA 模式改以 U 顯示。轉錄本保留已註解的非編碼區，未另外加入 poly(A) 尾；非編碼 RNA 的參考轉錄本也可能仍需後續加工。數字為所選序列的 1-based 位置。長序列以黃色捲軸瀏覽，可複製或下載完整轉錄本與蛋白質；基因組 DNA 隨捲動取得所需範圍。