ST6GAL1 — ST6 beta-galactoside alpha-2,6-sialyltransferase 1

01 / GENE OVERVIEW

基因總覽

ST6GAL1 是蛋白質編碼基因，其產物為 ST6 beta-galactoside alpha-2,6-sialyltransferase 1，屬於 glycosyltransferase 29 家族。這是一種單次穿膜的第二型膜蛋白，具有短的細胞質端、跨膜區段與較長的腔內區域。蛋白質主要以高基氏體膜上的膜結合形式存在，也有分泌至體液中的形式。其基本角色是催化醣鏈修飾，為細胞表面分子及其他蛋白質上的醣鏈添加唾液酸。

Official symbol

ST6GAL1

Gene name

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

Organism

Homo sapiens

Gene type

Protein coding

HGNC ID

HGNC:10860

UniProt

P15907

02 / NOMENCLATURE

基因異名與舊稱

Alternative gene names & synonyms

CDw75SIAT1

異名取自 HGNC，可能包含歷史名稱；蛋白質名稱以 UniProt 註解為準。

03 / GENOMIC CONTEXT

染色體位置與基因結構

Chromosome 33q27.3

GRCh38 / 1-based inclusiveDirection: forward strand (+)

Genomic coordinates

chr3:186,930,325–187,078,932

Gene span

148,608 bp

Strand

Forward (+)

Gene assembly

GRCh38

查看實際轉錄本與 exon 註解

Transcript	Genomic coordinates	Exons
ENST00000169298 ★	186,930,526–187,078,553	8
ENST00000879710	186,930,343–187,078,932	10
ENST00000879713	186,930,356–187,078,932	8
ENST00000955782	186,930,356–187,078,932	10
ENST00000955784	186,930,356–187,078,932	9
ENST00000677292	186,930,466–187,078,932	10
ENST00000879711	186,930,466–187,078,932	9
ENST00000879712	186,930,466–187,078,932	9
ENST00000879714	186,930,466–187,078,932	9
ENST00000879715	186,930,466–187,078,932	9
ENST00000879716	186,930,466–187,078,932	7
ENST00000879717	186,930,466–187,078,932	9

顯示 12/65 個蛋白質編碼轉錄本；canonical 優先。

帶型與著絲點依 Ensembl 座標繪製；核染色體長度以 GRCh38 第 1 號染色體為共同尺度。黃色標記表示本基因位置，細小區間加粗以利辨識；實際基因長度與 exon 見下方資料。

04 / BIOLOGICAL FUNCTION

分子功能與生物學過程

ST6 beta-galactoside alpha-2,6-sialyltransferase 1 將唾液酸由 CMP-sialic acid 轉移至含半乳糖的受體分子，形成 alpha-2,6 鍵結的唾液酸化產物。此反應可作用於不同的醣鏈受體，包含蛋白質上的複合型 N-醣鏈；其催化反應伴隨 CMP 釋出。這類醣基轉移作用屬於蛋白質修飾與蛋白質醣基化的一環。

在 B 淋巴球中，ST6GAL1 參與生成對 neuraminidase 敏感的淋巴球細胞表面分化抗原，例如 CDw75、HB-6 與 CD76。這些例子顯示，該酵素對細胞表面分子醣鏈的修飾，與淋巴球表面抗原的形成有關。

另一類受體是 IgG 的 fragment crystallizable（Fc）區所連接的複合型 N-醣鏈。ST6GAL1 可使這些醣鏈唾液酸化；來源指出，這種修飾可賦予 IgG 抗發炎效應功能。對 Fc 醣鏈而言，酵素優先在 alpha(1->3) mannose 分枝上添加一個唾液酸，形成單唾液酸化產物；後續再加上第二個唾液酸、形成雙唾液酸化的速度則慢得多。

其受體範圍也包括具有不同分枝與修飾形式的蛋白質 N-醣鏈。來源列出的反應涵蓋已帶有唾液酸或尚未唾液酸化的分枝，以及含或不含特定 N-乙醯葡萄糖胺、半乳糖與岩藻糖結構的醣鏈，顯示 ST6GAL1 能在多種複合型 N-醣鏈上催化 alpha-2,6 唾液酸化。這些反應共同說明，ST6GAL1 透過改變細胞表面抗原與蛋白質醣鏈的末端結構，參與醣鏈修飾及其相關功能。

05 / GENE REGULATION

Promoter 與基因調控

起點（bp）到終點（bp）

以 TSS = 0 為基準：負數為上游、正數為下游，包含起點與終點。每次最多取得 100,000 bp。

TSS 來源TSS: 186930526 · 正股

查看轉錄本與 TSS ↗

依所選 TSS 來源，取得指定上、下游範圍的基因組序列。

擷取區間依所選 TSS 計算；調控註解與實驗支持的 TSS 可在下方查閱。

>ST6GAL1 ENST00000169298 GRCh38 chr3:186929526-186930626 strand=1 5′→3′
相對 TSS：-1000 到 +100 bp；1101 bp
依轉錄本 TSS 擷取的基因組序列；TSS = 0，兩端包含，未驗證為 promoter
TGTGGGGTAGGCACCTCATTTGGAGACAGAACTCTGGGCCTGGGCTTCAGGCACTTTAAGTGTGCACTGG
ACTTTGTGTTCCCAGAGGACCCCCAAACCTTCCAGTATCTCCTTCCTTTCCCCTTTCCCACCCAGCACAC
AGCCTGGTGCCTAGTGTGCACTCAGTAGACAACTGGGATATGACTATTGCCTCTGGTAGTCACATCCTCT
CTTTGGGCTATGGGAGGCTGGACTGGAGGCCTTAAAGGCCCCTTCCGCCCTCCTGTTGGGCAGTTTTTCT
TTCTTAGGGAAATCGCCTTGGGGCTATCGGGGATGGTCAGTACGCAGCTTGGTTAATCCTCTTTCCTTCC
CCAGCAGCCCCACCGTCGTCCGGGTGAAAAGAAAGAACCTCGCTCCCTTCACCATCCAGGCTGAGGCTTC
AGTCTTTCAGCCTGCAGCTTGGGGTGGAAGCCTCTGGGTGCAGGGGTTCGAGGACGCTCCTCTCCTTCTG
TATTTGCCATTTGAGAGCGCCCAGTAGGAGTCATGCCTCAATGTTAGGAGGTTAATGCCAAACGCAGTGA
AAGATTTTGTTCTTTCCTATTCTAGATAAGAGCAACACGAGTCTTCGGAGAGGTTAAGCGACTTCCTCAG
GGTCTCGCAGTCAGCCGGTAGCAGAGACCGGGTGTACAGCACCCGCATGTTAGGACCAAAAGCCGGACAC
TGCTGGATTGACCCCTCGCGGCCAAGCGGGGAAGAGGCATTTAGGGGTCCTTGCGCAGCCGCGTGGCCCC
TCCCACTCGGCCCTCGATCCACCCTCCTTGAGAGCAGGCAGGATTCTAGCATCACCCAGTGCCTTCATCA
AGAGTCTTTAACCCCAAGCCCGCTCGCTAGCGACCTCCAGGCCGGTTTGGGGCGCGGTGTGGCCGGTGGC
GAGAGGTGGAGTGGGGGCGGAGACCGACCCAGTCTTCGCAACTCTATTTGCATACGGAGGCGACTCGCTT
CCTTCCCGCCCCTCCGCCGCGCTCTTCTTCCTTCCTTCTCCAGTCCCTTCCACTGTGCGTCTTCTGTCCC
CCGTTCTTCCCCAGCGGACCCCTCTTTCGAGACTCCCTAGTGGGGTCCCCA

ST6GAL1 位於正股。上下游依轉錄方向計算，序列一律以該方向的 5′→3′ 顯示；負股會取得反向互補序列。

EPDnew 實驗支持 promoter／TSS · 3 筆

EPDnew ID	TSS（1-based）	股向	來源顯示區間
ST6GAL1_1 ↗	3:186,930,526	正股	186,930,477–186,930,536
ST6GAL1_2 ↗	3:187,021,855	正股	187,021,806–187,021,865
ST6GAL1_3 ↗	3:187,025,483	正股	187,025,434–187,025,493

EPDnew human v006 · UCSC hg38，GRCh38/hg38，透過 UCSC 取得。TSS 具有 CAGE／RAMPAGE 等實驗資料支持；任意擷取的上下游區間仍需另行判讀調控功能，不能視為整段皆經功能驗證。

EPD 封存狀態 ↗ · UCSC 資料說明 ↗ · EPD team, SIB Swiss Institute of Bioinformatics; UCSC Genome Browser · CC BY 4.0

目前未取得此類註解。

序列擷取依所選 TSS 與相對範圍計算；該區間的調控功能需參照相應的實驗證據。

06 / PROTEIN ANATOMY

蛋白質結構域與序列

參考蛋白質長度：406 aa

依 P15907 的 UniProt 殘基座標與蛋白質長度繪製；結構域、DNA 結合區、功能區域與基序分列，重疊註解分行顯示。區域色彩區分類型，並非活性或信心分數。

ST6 beta-galactoside alpha-2,6-sialyltransferase 1 長 406 個胺基酸，屬於 glycosyltransferase 29 家族。其 N 端第 1–9 位為細胞質區，第 10–26 位為螺旋狀跨膜區，並作為第二型膜蛋白的訊號錨定區；第 27–406 位位於腔內。

拓樸區域Cytoplasmic1–9 aa

跨膜區Helical; Signal-anchor for type II membrane protein10–26 aa

拓樸區域Lumenal27–406 aa

查看 UniProt FASTA 序列 ↗

07 / STRUCTURAL BIOLOGY

蛋白質三維結構

自動載入 · 可拖曳旋轉與縮放

正在載入 PDB · 4JS1…

PDB · 4JS1

X-ray · 2.09 A · A=89-406

查看原始結構紀錄 ↗

實驗模型；依序列位置著色，可能只覆蓋局部區域。

08 / SUBCELLULAR LOCALIZATION

細胞內定位

定位：Golgi apparatus, Golgi stack membrane；Secreted

ST6GAL1 的膜結合型位於高基氏體 trans cisternae，並與 MGAT3、B4GALT1 在高基氏體堆疊中共定位，包括其 cis 區域。另有資料指出，該蛋白可分泌至體液中；此分泌定位屬於相似性推論。

UniProtKB

深綠色圓點：來源記載的蛋白質定位；數量不表示含量。

細胞外定位：圓點散佈於細胞周圍，與細胞膜保持距離。

動物細胞結構示意；器官大小與數量不按比例。點選細胞構造可查看定位註解。

09 / PROTEIN NETWORK

交互作用與訊號網絡

圖中 0 個夥伴 · 最多顯示 50 個

來源支持的結構／直接結合關係其他來源關係紀錄

拖曳節點後放開可帶動位置變化；點選夥伴查看證據。位置與連線長度不代表結合強度，圖中未推定夥伴彼此之間的關係。

更多交互作用夥伴 · 已取得 0 個夥伴

0 個夥伴

目前沒有已匯入的夥伴。

第 1 頁

查看 UniProt 完整互作來源 ↗

ST6GAL1 可呈單體或同源二聚體形式。來源未提供其與其他蛋白質形成實體結合或複合體的資訊。

10 / HUMAN HEALTH

疾病與遺傳關聯

目前未取得此類註解。

個別變異的臨床意義取決於其證據；基因層級的疾病關聯不能套用至所有變異。

11 / CONTEXTUAL FUNCTIONAL EVIDENCE MATRIX

Contextual Functional Evidence Matrix

功能證據與細胞情境矩陣

矩陣以「功能主張」為列，以細胞情境、干預條件、量測結果與證據來源為欄，方便比較同一功能在不同條件下的支持情形。只有含情境與實驗資訊的紀錄會列入矩陣；一般功能註解另列於下方。

14 筆功能證據／註解

目前尚無同時具備實驗情境與干預／量測資訊的證據列。可查核的功能敘述列於「功能註解總覽」，空白實驗欄位不以推測補齊。

功能註解總覽 · 14 筆

功能面向	功能敘述	證據類型	可查核來源
功能	ST6GAL1 將唾液酸由 CMP-sialic acid 轉移至含半乳糖的受體。在 B 淋巴球中，這項作用會生成對 neuraminidase 敏感的細胞表面分化抗原，包括 CDw75、HB-6 與 CD76。它也會唾液酸化 IgG 的 Fc 區複合型 N-醣鏈，賦予抗發炎效應功能；在 Fc 醣鏈上，優先修飾 alpha(1->3) mannose 分枝形成單唾液酸化產物，之後形成雙唾液酸化產物的速度較慢。	含實驗來源	證據與來源 Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76. Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs conferring anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate PMID 1730763 ↗ · PMID 21081508 ↗ · PMID 23999306 ↗ · PMID 25733881 ↗ · PMID 27872474 ↗ · PMID 36280670 ↗ · PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)	含實驗來源	證據與來源 a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) PMID 21081508 ↗ · PMID 23999306 ↗ · PMID 25733881 ↗ · PMID 36280670 ↗ · PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 25733881 ↗ · PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 25733881 ↗ · PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 36280670 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 36280670 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 36280670 ↗ · PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ 開啟資料庫紀錄 ↗
分子活性	an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)	含實驗來源	證據與來源 an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 36280670 ↗ 開啟資料庫紀錄 ↗
分子活性	ST6GAL1 參與蛋白質修飾，具體類別為蛋白質醣基化。	資料庫紀錄	證據與來源 Protein modification; protein glycosylation 開啟資料庫紀錄 ↗
交互作用	ST6GAL1 可呈現單體形式，也可形成同源二聚體。	含實驗來源	證據與來源 Monomer and homodimer PMID 20378551 ↗ 開啟資料庫紀錄 ↗
細胞定位	ST6GAL1 是單次穿膜的第二型膜蛋白，膜結合型位於高基氏體 trans cisternae；另有相似性推論指出它可分泌至體液。ST6GAL1 也與 MGAT3 和 B4GALT1 在高基氏體堆疊中共定位，涵蓋 cis 區域。	含實驗來源	證據與來源 Golgi apparatus, Golgi stack membrane / Single-pass type II membrane protein; Secreted; Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). Colocalizes with MGAT3 and B4GALT1 in the Golgi stacks of cisternae, including the cis-part of the Golgi stacks PMID 1730763 ↗ · PMID 20378551 ↗ · PMID 29133956 ↗ 開啟資料庫紀錄 ↗

情境矩陣 0 筆 · 一般功能註解 14 筆。互作清單與機器格式紀錄不列入本區。

證據分項判讀，不加總為單一可信度分數。「含實驗來源」依資料庫證據標記辨識；未逐篇核對原始方法的紀錄，不宣稱已完成實驗審查。

12 / SEQUENCE EXPLORER

核酸與蛋白質序列

完整轉錄本 · UTR / CDS 著色 · FASTA

轉錄本／異構型

序列類型

ENST00000169298 · 4,604 nt · GRCh38

依 Ensembl exon 註解拼接的 GRCh38 參考序列，保留非編碼區。

1GCTCTTCTTCCTTCCTTCTCCAGTCCCTTCCACTGTGCGT40

41CTTCTGTCCCCCGTTCTTCCCCAGCGGACCCCTCTTTCGA80

81GACTCCCTAGTGGGGTCCCCAGCTCCCGGGCGATCCTGCC120

121CTTGCCGAGCGCGTTTTCTGGAGTCACCTGGGGGAGGGGA160

161GTCCTGGGCAGGGCCGGGCTGGGGAAGACGCCTGGGGCAC200

201TGCCCGGCGTTAACAAAGGGAGCCGATACCGACCGGCGTG240

241GGCGCGGAGCGGGCGGCCGCCACCGAGCGTGCTGAGCAAC280

281CGCAGCCTCCGCGGCCGAGAGTGCAGCGAGCAAGGGGAGA320

321GCCAGTTGCGCAGAGCCCTGCAACCAGCAGTCCAGGGAGA360

361AGTGGTGAATGTCATGGAGCCCAGCTGAAATGGACTGGCC400

401CCCTTGAGCCTGTCCCAAGCCCTGGTGCCAGGTGTCCATC440

441CCCGTGCTGAGATGAGTTTTGATCATCCTGAGAAAAATGG480

481GCCTTGGCCTGCAGACCCAATAAACCTTCCCTCCCATGGA520

521TAATAGTGCTAATTCCTGAGGACCTGAAGGGCCTGCCGCC560

561CCTGGGGGATTAGCCAGAAGCAGGCTTGTTTTCCTGCTCA600

601GAACAAAGTGACTTCCCTGAACACATCTTCATTATGATTC640

641ACACCAACCTGAAGAAAAAGTTCAGCTGCTGCGTCCTGGT680

681CTTTCTTCTGTTTGCAGTCATCTGTGTGTGGAAGGAAAAG720

721AAGAAAGGGAGTTACTATGATTCCTTTAAATTGCAAACCA760

761AGGAATTCCAGGTGTTAAAGAGTCTGGGGAAATTGGCCAT800

801GGGGTCTGATTCCCAGTCTGTATCCTCAAGCAGCACCCAG840

841GACCCCCACAGGGGCCGCCAGACCCTCGGCAGTCTCAGAG880

881GCCTAGCCAAGGCCAAACCAGAGGCCTCCTTCCAGGTGTG920

921GAACAAGGACAGCTCTTCCAAAAACCTTATCCCTAGGCTG960

跳至位置

cDNA 使用 DNA 字母 T；mRNA 模式改以 U 顯示。轉錄本保留已註解的非編碼區，未另外加入 poly(A) 尾；非編碼 RNA 的參考轉錄本也可能仍需後續加工。數字為所選序列的 1-based 位置。長序列以黃色捲軸瀏覽，可複製或下載完整轉錄本與蛋白質；基因組 DNA 隨捲動取得所需範圍。

13 / DATA PROVENANCE

資料來源與研究連結

HGNC ↗NCBI Gene ↗Ensembl ↗UniProtKB ↗RCSB PDB · 4JS1 ↗EPDnew v006 · UCSC ↗

HGNC · CC0 ↗ · UniProt Consortium · CC BY 4.0 ↗ · Ensembl · 資料使用說明 ↗ · RCSB／wwPDB 結構資料 · CC0 ↗ · EPD team／SIB · CC BY 4.0 ↗

資料更新：2026-11-04

ST6GAL1CDw75

基因總覽

基因異名與舊稱

染色體位置與基因結構

分子功能與生物學過程

Promoter 與基因調控

蛋白質結構域與序列

蛋白質三維結構

PDB · 4JS1

細胞內定位

交互作用與訊號網絡

疾病與遺傳關聯

Contextual Functional Evidence Matrix

核酸與蛋白質序列

資料來源與研究連結