基因總覽
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 是由 ST3GAL4 編碼的蛋白質，屬於 glycosyltransferase 29 家族。它是單次跨膜的第二型膜蛋白，含有短的細胞質區、跨膜區及位於膜腔側的較長區段。其主要角色是催化糖鏈末端的唾液酸化，作用底物包括糖蛋白與糖脂。
基因異名與舊稱
異名取自 HGNC，可能包含歷史名稱；蛋白質名稱以 UniProt 註解為準。
染色體位置與基因結構
查看實際轉錄本與 exon 註解
| Transcript | Genomic coordinates | Exons |
|---|---|---|
| ENST00000444328 ★ | 126,355,686–126,414,638 | 11 |
| ENST00000966086 | 126,354,677–126,414,636 | 11 |
| ENST00000860622 | 126,355,630–126,414,638 | 10 |
| ENST00000966087 | 126,355,634–126,414,637 | 12 |
| ENST00001124064 | 126,355,634–126,414,629 | 11 |
| ENST00000356132 | 126,355,639–126,414,617 | 12 |
| ENST00000966088 | 126,355,639–126,414,636 | 10 |
| ENST00000860623 | 126,355,640–126,414,640 | 12 |
| ENST00000860624 | 126,355,649–126,414,638 | 11 |
| ENST00000966089 | 126,355,649–126,414,629 | 13 |
| ENST00000860625 | 126,355,654–126,414,638 | 11 |
| ENST00000860626 | 126,355,657–126,414,635 | 12 |
顯示 12/106 個蛋白質編碼轉錄本；canonical 優先。
帶型與著絲點依 Ensembl 座標繪製；核染色體長度以 GRCh38 第 1 號染色體為共同尺度。黃色標記表示本基因位置，細小區間加粗以利辨識；實際基因長度與 exon 見下方資料。
分子功能與生物學過程
ST3GAL4 催化唾液酸轉移：以 CMP-Neu5Ac 為供體，將唾液酸接到末端帶有 Galβ-(1→3)-GalNAc 或 Galβ-(1→4)-GlcNAc 的受體糖鏈上，形成 α2-3 鍵結。這項反應參與糖蛋白及糖脂的末端唾液酸化，也涵蓋多種 N-聚醣受體。
Promoter 與基因調控
>ST3GAL4 ENST00000444328 GRCh38 chr11:126354686-126355786 strand=1 5′→3′ 相對 TSS：-1000 到 +100 bp；1101 bp 依轉錄本 TSS 擷取的基因組序列；TSS = 0，兩端包含，未驗證為 promoter GCTGCCACTTCTCTGAACCCCCTTGCACTTACTGTCAGTCACTCACACCTTGCACTTATTCACATCCTAT CCTGCCTCGTTCTTGAATGGAGTCCATGGTGAGCCTTCTCTGTGCCGCTGGATGGTAAGCTTCCTGGGGA CAGGGAATGGGTCTGATAGTTTCCTTGGAGCCCCTGGCGCTCCCGGCACTGGGCTGTTGATACGTGGGGC TCCGGAAACACTGTGCTGACCTGTGAAAGGGACTGGCCTAAGGGGCTGTGGATTGTCCTGTAGGGTGACT TCTGAACTGTTCTTCAGCCTGGGCAGTTCCCAGGTTTATTTGGGGGGATGCCTGGGTCCAAAGAACCAGG GTCAGGGGCCCAGGGGTTTCTTCCTGGAGACAGGATGCCTGGCGCCTTCAATAACGGAAAGGAAACTGAG AAACTTTCTGAGGCCAAGATAAAGAGTATGCAAGTGAGGGGTGCAGAGAGAGCAGTTTAGGGGCAGCAGG CCCCAACCGAAGCAGAGGAAGGGCCCACGTCTGGGCCCAGGGGACTGACTGGCTGCCTTGCGTGCATGGG GCACGGGAAGCATAGGCTCCCGGAACAGGACCCTGCCCCAGTTTCCCCAGTGAGGGAAGGACACCGTTCC CCGTGGGATAGAGCACTGCACCCTTTCTTGATTCTCATTGTTCCCGGGAGCGAGCGCCTTGGCTGCGCTG GGCATACCCACCCTGGCGCCATTCACAGGCAGTGCCTGCCCTGGCCCTGTGCTCACCCCATCAGGCCTCC TCTTCCGCCTCTCTGGCACCCACGGCGCCCCTGCTTGCCTCTGTCCGGGTCTCGGAGGCGCGAACACCAT CCCAAGCCTGCGACCGCGCGGCATCACCCCCGCCCTTCCCCCTCCTCCACCCCGCCCTTTCTACCCCTCC CGGGAGCTCCTGGGAGTCGGGCCGCCGTGTGCGCAAGCGTGTCCAGCCCCTTCCCCGCCCCCAACCCGGG CCCGGGTCCCCGCCTCCCCTGCAGGCGGACTCGCCCGCTCCCAGGCCGGACCCGCGCCCGGGACAGGGAC CCGGCCGAGTCGAGCCGTCGCGCCAGCGCTGCGCCGCCGGTCGGTGCGCCT
EPDnew 實驗支持 promoter／TSS · 3 筆
| EPDnew ID | TSS（1-based） | 股向 | 來源顯示區間 |
|---|---|---|---|
| ST3GAL4_2 ↗ | 11:126,355,853 | 正股 | 126,355,804–126,355,863 |
| ST3GAL4_1 ↗ | 11:126,398,588 | 正股 | 126,398,539–126,398,598 |
| ST3GAL4_3 ↗ | 11:126,406,113 | 正股 | 126,406,064–126,406,123 |
EPDnew human v006 · UCSC hg38，GRCh38/hg38，透過 UCSC 取得。TSS 具有 CAGE／RAMPAGE 等實驗資料支持；任意擷取的上下游區間仍需另行判讀調控功能，不能視為整段皆經功能驗證。
EPD 封存狀態 ↗ · UCSC 資料說明 ↗ · EPD team, SIB Swiss Institute of Bioinformatics; UCSC Genome Browser · CC BY 4.0
查看已取得的調控／motif 註解
ENSR11_79FLC6 · enhancer · 126352310–126352435 · regulatory
ENSR11_D8995 · enhancer · 126353338–126355546 · regulatory
ENSR11_BX43M · promoter · 126355547–126356284 · regulatory
ENSR11_534PFXF · CTCF_binding_site · 126355763–126355784 · regulatory
ENSR11_CGJJD · enhancer · 126356285–126357558 · regulatory
ENSR11_534PGB8 · CTCF_binding_site · 126357885–126357906 · regulatory
ENSR11_85PBB2 · enhancer · 126358206–126358351 · regulatory
ENSR11_BX448 · enhancer · 126359321–126360322 · regulatory
ENSR11_534PGKP · CTCF_binding_site · 126359501–126359522 · regulatory
ENSR11_85PBCG · enhancer · 126360686–126360936 · regulatory
· motif · 126351127–126351133 · motif
· motif · 126353492–126353506 · motif
· motif · 126353499–126353510 · motif
· motif · 126355208–126355221 · motif
· motif · 126355208–126355221 · motif
· motif · 126355312–126355325 · motif
· motif · 126355312–126355325 · motif
· motif · 126355455–126355466 · motif
· motif · 126355625–126355636 · motif
· motif · 126355625–126355636 · motif
· motif · 126355754–126355765 · motif
· motif · 126355765–126355781 · motif
· motif · 126355913–126355925 · motif
· motif · 126355916–126355923 · motif
· motif · 126355961–126355977 · motif
· motif · 126355961–126355977 · motif
· motif · 126356271–126356286 · motif
· motif · 126356335–126356350 · motif
· motif · 126356458–126356471 · motif
· motif · 126356698–126356705 · motif
· motif · 126356698–126356713 · motif
· motif · 126356925–126356938 · motif
· motif · 126357169–126357182 · motif
· motif · 126357887–126357903 · motif
· motif · 126359503–126359519 · motif
· motif · 126359594–126359607 · motif
· motif · 126359612–126359625 · motif
蛋白質結構域與序列
參考蛋白質長度：333 aa
ST3GAL4 蛋白長 333 個胺基酸。第 1–8 位為細胞質區，第 9–26 位為螺旋跨膜區，並作為第二型膜蛋白的訊號錨定；第 27–333 位位於膜腔側。蛋白質屬於 glycosyltransferase 29 家族。
蛋白質三維結構
細胞內定位
ST3GAL4 可見於高基氏體堆疊膜，膜結合型位於高基氏體 trans cisternae；另有分泌至體液中的形式。
深綠色圓點：來源記載的蛋白質定位；數量不表示含量。
細胞外定位：圓點散佈於細胞周圍，與細胞膜保持距離。
動物細胞結構示意；器官大小與數量不按比例。點選細胞構造可查看定位註解。
交互作用與訊號網絡
拖曳節點後放開可帶動位置變化；點選夥伴查看證據。位置與連線長度不代表結合強度，圖中未推定夥伴彼此之間的關係。
疾病與遺傳關聯
Contextual Functional Evidence Matrix
矩陣以「功能主張」為列，以細胞情境、干預條件、量測結果與證據來源為欄，方便比較同一功能在不同條件下的支持情形。只有含情境與實驗資訊的紀錄會列入矩陣；一般功能註解另列於下方。
功能註解總覽 · 20 筆
| 功能面向 | 功能敘述 | 證據類型 | 可查核來源 |
|---|---|---|---|
| 功能 | ST3GAL4 將 CMP-Neu5Ac 的唾液酸以 α2-3 鍵結轉移至特定糖鏈，參與糖蛋白與糖脂的末端唾液酸化。此作用可修飾血漿 VWF，避免其被 ASGPR 辨識並清除；也調節 ASGPR 介導的血小板清除（此項為相似性推論）。此外，它參與 sialyl Lewis X 表位合成，與選擇素介導的白血球滾動及黏附相關；可能透過 CXCR2 的末端唾液酸化促進嗜中性球黏附與跨內皮遷移。其糖脂作用包括將 GM1、GA1 分別轉為 GD1a、GM1b，將 GT1c 轉為 GQ1c（相似性推論），並合成周邊神經髓鞘的重要結構成分 LM1。 | 含實驗來源 | 證據與來源A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage. Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation. Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively. Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin PMID 25498912 ↗ · PMID 37632720 ↗ · PMID 8288606 ↗ · PMID 8611500 ↗ |
| 分子活性 | a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) | 含實驗來源 | 證據與來源a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) PMID 8288606 ↗ |
| 分子活性 | a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) | 含實驗來源 | 證據與來源a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) PMID 8288606 ↗ |
| 分子活性 | a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) | 含實驗來源 | 證據與來源a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) PMID 37632720 ↗ · PMID 8288606 ↗ · PMID 8611500 ↗ |
| 分子活性 | a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+) | 含實驗來源 | 證據與來源a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+) PMID 8288606 ↗ |
| 分子活性 | a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+) | 含實驗來源 | 證據與來源a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+) PMID 8288606 ↗ |
| 分子活性 | a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+) | 推論支持 | 證據與來源a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+) |
| 分子活性 | a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) | 含實驗來源 | 證據與來源a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) PMID 8611500 ↗ |
| 分子活性 | a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+) | 推論支持 | 證據與來源a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+) PMID 8611500 ↗ |
| 分子活性 | an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP + 2 H(+) | 含實驗來源 | 證據與來源an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP + 2 H(+) PMID 37632720 ↗ |
| 分子活性 | an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) | 含實驗來源 | 證據與來源an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ |
| 分子活性 | an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) | 含實驗來源 | 證據與來源an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ |
| 分子活性 | an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) | 含實驗來源 | 證據與來源an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ |
| 分子活性 | an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) | 含實驗來源 | 證據與來源an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ |
| 分子活性 | an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP + 2 H(+) | 含實驗來源 | 證據與來源an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 CMP + 2 H(+) PMID 37632720 ↗ |
| 分子活性 | an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) | 含實驗來源 | 證據與來源an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ |
| 分子活性 | an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) | 含實驗來源 | 證據與來源an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+) PMID 37632720 ↗ |
| 分子活性 | 此註記將相關活動歸類為蛋白質修飾，並指出其涉及蛋白質糖基化；未提供更具體的底物、反應條件或作用結果。 | 資料庫紀錄 | |
| 分子活性 | 此註記將相關活動歸類為糖脂生合成，未進一步列出特定糖脂底物、反應步驟或產物。 | 資料庫紀錄 | |
| 細胞定位 | ST3GAL4 的定位註記包括高基氏體堆疊膜；其膜結合型位於高基氏體 trans cisternae，並記載有分泌至體液中的形式。 | 資料庫紀錄 | 證據與來源Golgi apparatus, Golgi stack membrane / Single-pass type II membrane protein; Secreted; Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid |
核酸與蛋白質序列
GCAGGCGGACTCGCCCGCTCCCAGGCCGGACCCGCGCCCG40GGACAGGGACCCGGCCGAGTCGAGCCGTCGCGCCAGCGCT80GCGCCGCCGGTCGGTGCGCCTAGCGGATCGGAGCTGCGCG120CGGAACCGTGCTGCCCCGCCCCGCTCCACCCGTGAGGGTG160GCCCGAGGCAGCCGGGATGACAGCTCTCCCCAGGAATCCT200GCTGCCTGCTGAGAAACATGGTCAGCAAGTCCCGCTGGAA240GCTCCTGGCCATGTTGGCTCTGGTCCTGGTCGTCATGGTG280TGGTATTCCATCTCCCGGGAAGACAGGTACATCGAGCTTT320TTTATTTTCCCATCCCAGAGAAGAAGGAGCCGTGCCTCCA360GGGTGAGGCAGAGAGCAAGGCCTCTAAGCTCTTTGGCAAC400TACTCCCGGGATCAGCCCATCTTCCTGCGGCTTGAGGATT440ATTTCTGGGTCAAGACGCCATCTGCTTACGAGCTGCCCTA480TGGGACCAAGGGGAGTGAGGATCTGCTCCTCCGGGTGCTA520GCCATCACCAGCTCCTCCATCCCCAAGAACATCCAGAGCC560TCAGGTGCCGCCGCTGTGTGGTCGTGGGGAACGGGCACCG600GCTGCGGAACAGCTCACTGGGAGATGCCATCAACAAGTAC640GATGTGGTCATCAGATTGAACAATGCCCCAGTGGCTGGCT680ATGAGGGTGACGTGGGCTCCAAGACCACCATGCGTCTCTT720CTACCCTGAATCTGCCCACTTCGACCCCAAAGTAGAAAAC760AACCCAGACACACTCCTCGTCCTGGTAGCTTTCAAGGCAA800TGGACTTCCACTGGATTGAGACCATCCTGAGTGATAAGAA840GCGGGTGCGAAAGGGTTTCTGGAAACAGCCTCCCCTCATC880TGGGATGTCAATCCTAAACAGATTCGGATTCTCAACCCCT920TCTTCATGGAGATTGCAGCTGACAAACTGCTGAGCCTGCC960cDNA 使用 DNA 字母 T；mRNA 模式改以 U 顯示。轉錄本保留已註解的非編碼區，未另外加入 poly(A) 尾；非編碼 RNA 的參考轉錄本也可能仍需後續加工。數字為所選序列的 1-based 位置。長序列以黃色捲軸瀏覽，可複製或下載完整轉錄本與蛋白質；基因組 DNA 隨捲動取得所需範圍。